PROTONIX is supplied as delayed-release granules in packets for preparation of oral suspensions or as delayed-release tablets. The recommended dosages are outlined in Table 1.
Short-Term Treatment of Erosive Esophagitis Associated With GERD
Once daily for up to 8 weeks*
Children (5 years and older)
≥ 15 kg to < 40 kg
Once daily for up to 8 weeks
≥ 40 kg
Maintenance of Healing of Erosive Esophagitis
Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome
Directions for method of administration for each dosage form are presented in Table 2.
Swallowed whole, with or without food
For Delayed-Release Oral Suspension
Administered in 1 teaspoonful of applesauce or apple juice approximately 30 minutes prior to a meal
See instructions below
Take a missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular scheduled time. Do not take 2 doses at the same time.
PROTONIX Delayed-Release Tablets
Swallow PROTONIX Delayed-Release Tablets whole, with or without food in the stomach. For patients unable to swallow a 40 mg tablet, two 20 mg tablets may be taken. Concomitant administration of antacids does not affect the absorption of PROTONIX Delayed-Release Tablets.
PROTONIX For Delayed-Release Oral Suspension
Administer PROTONIX For Delayed-Release Oral Suspension approximately 30 minutes prior to a meal via oral administration in apple juice or applesauce or nasogastric tube in apple juice only. Because proper pH is necessary for stability, do not administer PROTONIX For Delayed-Release Oral Suspension in liquids other than apple juice, or foods other than applesauce.
Do not divide the 40 mg PROTONIX For Delayed-Release Oral Suspension packet to create a 20 mg dosage for pediatric patients who are unable to take the tablet formulation.
PROTONIX For Delayed-Release Oral Suspension - Oral Administration in Applesauce
PROTONIX For Delayed-Release Oral Suspension - Oral Administration in Apple Juice
PROTONIX For Delayed-Release Oral Suspension - Nasogastric (NG) Tube or Gastrostomy Tube Administration
For patients who have a nasogastric tube or gastrostomy tube in place, PROTONIX For Delayed-Release Oral Suspension can be given as follows:
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