PREMARIN® VAGINAL CREAM Contraindications

(conjugated estrogens)

4 CONTRAINDICATIONS

PREMARIN Vaginal Cream therapy should not be used in women with any of the following conditions:

Undiagnosed abnormal genital bleeding
Known, suspected, or history of breast cancer
Known or suspected estrogen-dependent neoplasia
Active DVT, PE, or a history of these conditions
Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
Known anaphylactic reaction or angioedema to PREMARIN Vaginal Cream
Known liver dysfunction or disease
Known protein C, protein S or antithrombin deficiency or other known thrombophilic disorders
Known or suspected pregnancy

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Contraindications

4 CONTRAINDICATIONS

PREMARIN Vaginal Cream therapy should not be used in women with any of the following conditions:

Undiagnosed abnormal genital bleeding
Known, suspected, or history of breast cancer
Known or suspected estrogen-dependent neoplasia
Active DVT, PE, or a history of these conditions
Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
Known anaphylactic reaction or angioedema to PREMARIN Vaginal Cream
Known liver dysfunction or disease
Known protein C, protein S or antithrombin deficiency or other known thrombophilic disorders
Known or suspected pregnancy
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