XALKORI® What is XALKORI?

(crizotinib)

What is XALKORI?

•
adults with non-small cell lung cancer (NSCLC) that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1.
•
children 1 year of age and older and young adults with ALCL when your ALCL with a defect in a gene called ALK has returned or you have tried a treatment and it did not work or is no longer working.
o
It is not known if XALKORI is safe and effective in older adults with ALCL.
•
adults and children 1 year of age and older with IMT when your IMT with a defect in a gene called ALK cannot be removed by surgery, has returned, or you have tried a treatment and it did not work or is no longer working.

It is not known if XALKORI is safe and effective in children younger than 1 year of age with ALCL or IMT, or in any children with NSCLC.

Before taking XALKORI, tell your healthcare provider about all of your medical conditions, including if you:

•
have liver or kidney problems
•
have lung problems
•
have heart problems, including a condition called long QT syndrome
•
have vision or eye problems
•
are pregnant or plan to become pregnant. XALKORI can harm your unborn baby.
Females who are able to become pregnant:
o
Your healthcare provider will check to see if you are pregnant before starting treatment with XALKORI.
o
Effective birth control (contraception) should be used during treatment with XALKORI and for 45 days after the last dose of XALKORI.
o
Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with XALKORI.
 
Males who have female partners who can become pregnant:
o
You should use condoms during treatment with XALKORI and for 90 days after the last dose of XALKORI.
•
are breastfeeding or plan to breastfeed. It is not known if XALKORI passes into your breast milk. Do not breastfeed during treatment with XALKORI and for 45 days after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. XALKORI can affect the way other medicines work, and other medicines can affect how XALKORI works.

Find XALKORI® medical information:

Find XALKORI® medical information:

Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

XALKORI® Quick Finder

Medication Guide

Health Professional Information

What is XALKORI?

What is XALKORI?

•
adults with non-small cell lung cancer (NSCLC) that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1.
•
children 1 year of age and older and young adults with ALCL when your ALCL with a defect in a gene called ALK has returned or you have tried a treatment and it did not work or is no longer working.
o
It is not known if XALKORI is safe and effective in older adults with ALCL.
•
adults and children 1 year of age and older with IMT when your IMT with a defect in a gene called ALK cannot be removed by surgery, has returned, or you have tried a treatment and it did not work or is no longer working.

It is not known if XALKORI is safe and effective in children younger than 1 year of age with ALCL or IMT, or in any children with NSCLC.

Before taking XALKORI, tell your healthcare provider about all of your medical conditions, including if you:

•
have liver or kidney problems
•
have lung problems
•
have heart problems, including a condition called long QT syndrome
•
have vision or eye problems
•
are pregnant or plan to become pregnant. XALKORI can harm your unborn baby.
Females who are able to become pregnant:
o
Your healthcare provider will check to see if you are pregnant before starting treatment with XALKORI.
o
Effective birth control (contraception) should be used during treatment with XALKORI and for 45 days after the last dose of XALKORI.
o
Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with XALKORI.
 
Males who have female partners who can become pregnant:
o
You should use condoms during treatment with XALKORI and for 90 days after the last dose of XALKORI.
•
are breastfeeding or plan to breastfeed. It is not known if XALKORI passes into your breast milk. Do not breastfeed during treatment with XALKORI and for 45 days after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. XALKORI can affect the way other medicines work, and other medicines can affect how XALKORI works.
Prescribing Information
Download Prescribing Information

Health Professional Information

What is XALKORI?

What is XALKORI?

•
adults with non-small cell lung cancer (NSCLC) that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1.
•
children 1 year of age and older and young adults with ALCL when your ALCL with a defect in a gene called ALK has returned or you have tried a treatment and it did not work or is no longer working.
o
It is not known if XALKORI is safe and effective in older adults with ALCL.
•
adults and children 1 year of age and older with IMT when your IMT with a defect in a gene called ALK cannot be removed by surgery, has returned, or you have tried a treatment and it did not work or is no longer working.

It is not known if XALKORI is safe and effective in children younger than 1 year of age with ALCL or IMT, or in any children with NSCLC.

Before taking XALKORI, tell your healthcare provider about all of your medical conditions, including if you:

•
have liver or kidney problems
•
have lung problems
•
have heart problems, including a condition called long QT syndrome
•
have vision or eye problems
•
are pregnant or plan to become pregnant. XALKORI can harm your unborn baby.
Females who are able to become pregnant:
o
Your healthcare provider will check to see if you are pregnant before starting treatment with XALKORI.
o
Effective birth control (contraception) should be used during treatment with XALKORI and for 45 days after the last dose of XALKORI.
o
Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with XALKORI.
 
Males who have female partners who can become pregnant:
o
You should use condoms during treatment with XALKORI and for 90 days after the last dose of XALKORI.
•
are breastfeeding or plan to breastfeed. It is not known if XALKORI passes into your breast milk. Do not breastfeed during treatment with XALKORI and for 45 days after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. XALKORI can affect the way other medicines work, and other medicines can affect how XALKORI works.

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