PAXLOVID can interact with other medicines causing severe or life-threatening side effects or death. It is important to know the medicines that should not be taken with PAXLOVID.
Do not take PAXLOVID if:
These are not the only medicines that may cause serious or life-threatening side effects if taken with PAXLOVID. PAXLOVID may increase or decrease the levels of multiple other medicines. It is very important to tell your healthcare provider about all of the medicines you are taking because additional laboratory tests or changes in the dose of your other medicines may be necessary during treatment with PAXLOVID. Your healthcare provider may also tell you about specific symptoms to watch out for that may indicate that you need to stop or decrease the dose of some of your other medicines.
PAXLOVID is not approved for use as pre-exposure or post-exposure treatment for prevention of COVID-19.
Before taking PAXLOVID, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Tell your healthcare provider if you are taking combined birth control (hormonal contraceptive). PAXLOVID may affect how your hormonal contraceptives work. Females who are able to become pregnant should use another effective alternative form of contraception or an additional barrier method of contraception during treatment with PAXLOVID. Talk to your healthcare provider if you have any questions about contraceptive methods that might be right for you.
If you are prescribed PAXLOVID 300 mg; 100 mg Dose Pack
Each dose contains 3 tablets taken together twice daily
How to take PAXLOVID 300 mg; 100 mg Dose Pack
Morning Dose:
Take the 2 pink nirmatrelvir tablets and
1 white to off-white ritonavir tablet together.
Bedtime Dose:
Take the 2 pink nirmatrelvir tablets and
1 white to off-white ritonavir tablet together.
If you are prescribed PAXLOVID 150 mg; 100 mg Dose Pack
Each dose contains 2 tablets taken together twice daily
How to take PAXLOVID 150 mg; 100 mg Dose Pack
Morning Dose:
Take the 1 pink nirmatrelvir tablet and
1 white ritonavir tablet together.
Bedtime Dose:
Take the 1 pink nirmatrelvir tablet and
1 white ritonavir tablet together.
If you are prescribed PAXLOVID 300 mg; 100 mg (Day 1) and 150 mg; 100 mg (Days 2-5)
Each dose is taken together once daily; on days of dialysis take PAXLOVID after receiving dialysis
How to take PAXLOVID 300 mg; 100 mg (Day 1) and 150 mg; 100 mg (Days 2-5)
Day 1 (First Day):
Take the 2 pink nirmatrelvir tablets and
1 white ritonavir tablet together
(Blue part of the blister card).
Days 2-5:
Take the 1 pink nirmatrelvir tablet and
1 white ritonavir tablet together
Talk to your healthcare provider if you do not feel better or if you feel worse after 5 days.
PAXLOVID may cause serious side effects, including:
The most common side effects of PAXLOVID include: altered sense of taste (such as metallic, bitter taste) and diarrhea.
Other possible side effects include:
These are not all of the possible side effects of PAXLOVID. For more information, ask your healthcare provider or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep PAXLOVID and all medicines out of the reach of children.
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use PAXLOVID for a condition for which it was not prescribed. Do not give PAXLOVID to other people, even if they have the same symptoms that you have. It may harm them. You can ask your healthcare provider or pharmacist for more information about PAXLOVID that is written for health professionals.
Advise the patient to read the FDA-approved patient labeling (Patient Information).
Drug Interactions
Inform patients that PAXLOVID may interact with certain drugs and is contraindicated for use with certain drugs; therefore, advise patients to report to their healthcare provider the use of any prescription, non-prescription medication, or herbal products [see Boxed Warning, Contraindications (4), Warnings and Precautions (5.1), and Drug Interactions (7)].
Hypersensitivity Reactions
Inform patients that anaphylaxis, serious skin reactions, and other hypersensitivity reactions have been reported, even following a single dose of PAXLOVID. Advise them to immediately discontinue the drug and to inform their healthcare provider at the first sign of a skin rash, hives or other skin reactions, difficulty in swallowing or breathing, any swelling suggesting angioedema (for example, swelling of the lips, tongue, face, tightness of the throat, hoarseness), or other symptoms of an allergic reaction [see Warnings and Precautions (5.2)].
Dosage Modification in Patients with Renal Impairment
Moderate Renal Impairment
To ensure appropriate dosing in patients with moderate renal impairment, instruct such patients that they will be taking one 150 mg nirmatrelvir tablet with one 100 mg ritonavir tablet together twice daily for 5 days [see Dosage and Administration (2.3)].
Severe Renal Impairment (Including Those Requiring Hemodialysis)
To ensure appropriate dosing in patients with severe renal impairment, including those requiring hemodialysis, instruct patients that they will be taking two 150 mg nirmatrelvir tablets with one 100 mg ritonavir tablet together once on Day 1, followed by one 150 mg nirmatrelvir tablet with one 100 mg ritonavir together once daily on Days 2-5. Instruct patients to take their dose at approximately the same time each day. On days when patients undergo hemodialysis, instruct them to take the PAXLOVID dose after hemodialysis [see Dosage and Administration (2.3)].
Administration Instructions
Inform patients to take PAXLOVID with or without food at approximately the same time each day as instructed. Advise patients to swallow all tablets for PAXLOVID whole and not to chew, break, or crush the tablets. Alert the patient of the importance of completing the full 5-day treatment course and to continuing isolation in accordance with public health recommendations to maximize viral clearance and minimize transmission of SARS-CoV-2. If the patient misses a dose of PAXLOVID within 8 hours of the time it is usually taken, the patient should take it as soon as possible and resume the normal dosing schedule. If the patient misses a dose by more than 8 hours, the patient should not take the missed dose and instead take the next dose at the regularly scheduled time. The patient should not double the dose to make up for a missed dose [see Dosage and Administration (2)].
PATIENT INFORMATION | |||||
What is the most important information I should know about PAXLOVID? PAXLOVID can interact with other medicines causing severe or life-threatening side effects or death. It is important to know the medicines that should not be taken with PAXLOVID. Do not take PAXLOVID if:
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These are not the only medicines that may cause serious or life-threatening side effects if taken with PAXLOVID. PAXLOVID may increase or decrease the levels of multiple other medicines. It is very important to tell your healthcare provider about all of the medicines you are taking because additional laboratory tests or changes in the dose of your other medicines may be necessary during treatment with PAXLOVID. Your healthcare provider may also tell you about specific symptoms to watch out for that may indicate that you need to stop or decrease the dose of some of your other medicines.
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What is PAXLOVID? PAXLOVID is not approved for use as pre-exposure or post-exposure treatment for prevention of COVID-19. | |||||
Before taking PAXLOVID, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Tell your healthcare provider if you are taking combined birth control (hormonal contraceptive). PAXLOVID may affect how your hormonal contraceptives work. Females who are able to become pregnant should use another effective alternative form of contraception or an additional barrier method of contraception during treatment with PAXLOVID. Talk to your healthcare provider if you have any questions about contraceptive methods that might be right for you. | |||||
How should I take PAXLOVID?
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If you are prescribed PAXLOVID 300 mg; 100 mg Dose Pack | |||||
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How to take PAXLOVID 300 mg; 100 mg Dose Pack | |||||
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Morning Dose: |
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Bedtime Dose: |
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If you are prescribed PAXLOVID 150 mg; 100 mg Dose Pack | |||||
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How to take PAXLOVID 150 mg; 100 mg Dose Pack | |||||
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Morning Dose: |
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Bedtime Dose: |
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If you are prescribed PAXLOVID 300 mg; 100 mg (Day 1) and 150 mg; 100 mg (Days 2-5) | |||||
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How to take PAXLOVID 300 mg; 100 mg (Day 1) and 150 mg; 100 mg (Days 2-5) | |||||
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Day 1 (First Day): Take the 2 pink nirmatrelvir tablets and |
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Days 2-5: Take the 1 pink nirmatrelvir tablet and 1 white ritonavir tablet together | |||||
Talk to your healthcare provider if you do not feel better or if you feel worse after 5 days. | |||||
What are the possible side effects of PAXLOVID? PAXLOVID may cause serious side effects, including:
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The most common side effects of PAXLOVID include: altered sense of taste (such as metallic, bitter taste) and diarrhea. Other possible side effects include:
These are not all of the possible side effects of PAXLOVID. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. | |||||
How should I store PAXLOVID?
Keep PAXLOVID and all medicines out of the reach of children. | |||||
General information about the safe and effective use of PAXLOVID. | |||||
What are the ingredients in PAXLOVID? | |||||
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This Patient Information has been approved by the U.S. Food and Drug Administration. Revised: 02/2025
*Contact Medical Information. 9AM-5PM ET Monday to Friday; excluding holidays.
Pfizer Safety
To report an adverse event related to a Pfizer product and you are not part of a clinical trial* for this product, click the link below to submit your information:
Pfizer Safety Reporting Site
*If you are involved in a clinical trial for this product, adverse events should be reported to your coordinating study site.
If you cannot use the above website, or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at (800) 438-1985.
FDA Medwatch
You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatch or call (800) 822-7967.