mitoxantrone injection, USP What is the most important information I should know about MitoXANTRONE?

()

What is the most important information I should know about MitoXANTRONE?

MitoXANTRONE can cause serious side effects, including:

decrease in the ability of your bone marrow to make blood cells (myelosuppression). Your doctor may do blood tests during treatment with MitoXANTRONE to check your blood cell counts. The symptoms of myelosuppression can include:
- feeling tired
- increased infections
- bruising and bleeding easily

heart problems (congestive heart failure) that may lead to death even in people who have never had heart problems before. Heart failure can happen while you receive MitoXANTRONE, or months to years after you stop receiving MitoXANTRONE. Your risk of heart failure increases the more MitoXANTRONE you receive.
Call your doctor or get medical help right away if you have any of these problems during or after treatment with MitoXANTRONE:
- shortness of breath
- swelling of your ankles or feet
- sudden weight gain
- fast heartbeat or pounding in your chest
Before receiving MitoXANTRONE for the first time, you should have the following tests done:
- physical examination
- a test to check your heart's electrical activity (electrocardiogram)
- a test to check your heart's ability to pump blood
If you receive MitoXANTRONE to treat Multiple Sclerosis (MS), your doctor should also do the tests above:
- before you receive each MitoXANTRONE dose
- yearly after you stop receiving MitoXANTRONE treatment

acute myeloid leukemia (AML). Receiving MitoXANTRONE increases your risk of AML. AML is a cancer of the blood-forming cells of your bone marrow. Symptoms of AML can include:

feeling unusually tired and weak
increased infections
bruising and bleeding easily
fever

pain in your bones
trouble breathing
unexplained weight loss
night sweats

skin problems at your injection site. If MitoXANTRONE leaks out of your vein, skin problems can happen that may lead to serious skin damage (necrosis). Necrosis may need to be repaired surgically. Tell your doctor right away if you have any of the following problems at your injection site:

redness
swelling
pain

burning
skin turns a bluish color

Find mitoxantrone injection, USP medical information:

Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

mitoxantrone injection, USP Quick Finder

Medication Guide

Health Professional Information

What is the most important information I should know about MitoXANTRONE?

MitoXANTRONE can cause serious side effects, including:

decrease in the ability of your bone marrow to make blood cells (myelosuppression). Your doctor may do blood tests during treatment with MitoXANTRONE to check your blood cell counts. The symptoms of myelosuppression can include:
- feeling tired
- increased infections
- bruising and bleeding easily

heart problems (congestive heart failure) that may lead to death even in people who have never had heart problems before. Heart failure can happen while you receive MitoXANTRONE, or months to years after you stop receiving MitoXANTRONE. Your risk of heart failure increases the more MitoXANTRONE you receive.
Call your doctor or get medical help right away if you have any of these problems during or after treatment with MitoXANTRONE:
- shortness of breath
- swelling of your ankles or feet
- sudden weight gain
- fast heartbeat or pounding in your chest
Before receiving MitoXANTRONE for the first time, you should have the following tests done:
- physical examination
- a test to check your heart's electrical activity (electrocardiogram)
- a test to check your heart's ability to pump blood
If you receive MitoXANTRONE to treat Multiple Sclerosis (MS), your doctor should also do the tests above:
- before you receive each MitoXANTRONE dose
- yearly after you stop receiving MitoXANTRONE treatment

acute myeloid leukemia (AML). Receiving MitoXANTRONE increases your risk of AML. AML is a cancer of the blood-forming cells of your bone marrow. Symptoms of AML can include:

feeling unusually tired and weak
increased infections
bruising and bleeding easily
fever

pain in your bones
trouble breathing
unexplained weight loss
night sweats

skin problems at your injection site. If MitoXANTRONE leaks out of your vein, skin problems can happen that may lead to serious skin damage (necrosis). Necrosis may need to be repaired surgically. Tell your doctor right away if you have any of the following problems at your injection site:

redness
swelling
pain

burning
skin turns a bluish color

Prescribing Information

Download Prescribing Information

Health Professional Information

What is the most important information I should know about MitoXANTRONE?

MitoXANTRONE can cause serious side effects, including:

decrease in the ability of your bone marrow to make blood cells (myelosuppression). Your doctor may do blood tests during treatment with MitoXANTRONE to check your blood cell counts. The symptoms of myelosuppression can include:
- feeling tired
- increased infections
- bruising and bleeding easily

heart problems (congestive heart failure) that may lead to death even in people who have never had heart problems before. Heart failure can happen while you receive MitoXANTRONE, or months to years after you stop receiving MitoXANTRONE. Your risk of heart failure increases the more MitoXANTRONE you receive.
Call your doctor or get medical help right away if you have any of these problems during or after treatment with MitoXANTRONE:
- shortness of breath
- swelling of your ankles or feet
- sudden weight gain
- fast heartbeat or pounding in your chest
Before receiving MitoXANTRONE for the first time, you should have the following tests done:
- physical examination
- a test to check your heart's electrical activity (electrocardiogram)
- a test to check your heart's ability to pump blood
If you receive MitoXANTRONE to treat Multiple Sclerosis (MS), your doctor should also do the tests above:
- before you receive each MitoXANTRONE dose
- yearly after you stop receiving MitoXANTRONE treatment

acute myeloid leukemia (AML). Receiving MitoXANTRONE increases your risk of AML. AML is a cancer of the blood-forming cells of your bone marrow. Symptoms of AML can include:

feeling unusually tired and weak
increased infections
bruising and bleeding easily
fever

pain in your bones
trouble breathing
unexplained weight loss
night sweats

skin problems at your injection site. If MitoXANTRONE leaks out of your vein, skin problems can happen that may lead to serious skin damage (necrosis). Necrosis may need to be repaired surgically. Tell your doctor right away if you have any of the following problems at your injection site:

redness
swelling
pain

burning
skin turns a bluish color

Resources

Didn’t find what you were looking for? Contact us.

MI Digital Assistant

Chat online with Pfizer Medical Information regarding your inquiry on a Pfizer medicine.

Call 800-438-1985^*

*Contact Medical Information.9AM-5PM ET Monday to Friday; excluding holidays.

Report Adverse Event

Pfizer Safety

To report an adverse event related to the Pfizer-BioNTech COVID-19 Vaccine, and you are not part of a clinical trial* for this product, click the link below to submit your information:

Pfizer Safety Reporting Site

*If you are involved in a clinical trial for this product, adverse events should be reported to your coordinating study site.

If you cannot use the above website, or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at (800) 438-1985.

FDA Medwatch

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatch or call (800) 822-7967.