Instructions for UseNIVESTYM (Neye-ves-tim)(filgrastim-aafi)injectionSingle-Dose Prefilled Syringe
Read the Patient Information for important information you need to know about NIVESTYM before using this Instructions for Use.
Before you use a NIVESTYM prefilled syringe, read this important information.
Storing your prefilled syringe
Using your prefilled syringe
Call your healthcare provider if you have any questions.
About the NIVESTYM prefilled syringe
NIVESTYM prefilled syringe parts (see Figure A).
NIVESTYM 300 mcg/0.5 mL prefilled syringe is shown as an example.
What you need for your injection
Included in the carton:
Not included in the carton (see Figure B)
Figure C shows a needle guard that has not yet been activated. The prefilled syringe is ready for use. This is what the prefilled syringe looks like before use.
Figure D shows a needle guard that has been activated. This is what the prefilled syringe looks like after use.
Preparing the NIVESTYM prefilled syringe
Find a clean, well-lit flat work surface.
Take the carton containing the NIVESTYM prefilled syringe out of the refrigerator and leave it unopened on your work surface for at least 30 minutes so that it reaches room temperature. Put the original carton with any unused prefilled syringes back in the refrigerator.
Wash your hands with soap and water.
Remove the prefilled syringe from the carton. Check to make sure that the needle guard is covering the barrel of the prefilled syringe. Do not push the needle guard over the needle cover before the injection. This may activate or lock the needle guard. See Figure C above that shows how the prefilled syringe looks before use.If the needle guard is covering the needle that means it has been activated. See Figure D above that shows how the prefilled syringe looks after use. Do not use the NIVESTYM prefilled syringe. Get another prefilled syringe that has not been activated and is ready to use.
Check the expiration date on the NIVESTYM prefilled syringe. Do not use the NIVESTYM prefilled syringe if the expiration date has passed.
Inspect the medicine and prefilled syringe. Turn the prefilled syringe so you can see the medicine and markings in the window. Look through the window on the NIVESTYM prefilled syringe. Make sure the medicine in the prefilled syringe is clear and colorless.
Choose the injection site
Clean your injection site with an alcohol wipe. See Figure F.
Hold the prefilled syringe by the needle guard with the needle cover pointing up. Carefully pull the needle cover straight off and away from your body. Throw away the needle cover. Do not recap the needle. See Figure G.
Your healthcare provider has prescribed either a "full" syringe dose or a "partial" syringe dose.
Point the needle up and tap gently until the air rises to the top. See Figure H.
Holding the prefilled syringe as shown, slowly push up on the plunger rod to push out the extra air and medicine until the end of the conical base (edge) of the plunger stopper lines up with the syringe marking for your prescribed dose. See Figure I for an example of a dose of 0.3 mL. Your dose may be different than the example shown.Be careful not to activate the needle guard before use. Do not use a NIVESTYM prefilled syringe that has been activated.Check again to make sure the correct dose of NIVESTYM is in the prefilled syringe.
Administering the NIVESTYM prefilled syringe
With one hand, gently pinch a fold of skin at the injection site. Hold the pinch. See Figure J.
With your other hand, hold the prefilled syringe like you would hold a pencil. Use a quick "dart-like" motion to insert the needle at a 45 to 90 degree angle into the skin as shown. See Figure K.
Using slow and constant pressure, press down on the plunger rod as far as it will go. Keep the plunger rod fully pressed down while you hold the prefilled syringe in place for 5 seconds. See Figure L.
Keep the plunger rod fully pressed down while you carefully pull the needle straight out from the injection site. See Figure M.
As you let go of the plunger rod, the needle guard will automatically slide over the needle until the needle is completely covered and the needle guard locks into place. Do not recap the needle. See Figure N.
There may be a small amount of blood at the injection site. You can press a cotton ball or gauze over the injection site and hold it for 10 seconds. Do not rub the injection site. You may cover the injection site with a small adhesive bandage, if needed. See Figure O.
Throw away (dispose of) the syringe as instructed by your healthcare provider or by following the instructions below. See Figure P.
Disposing of (throw away) used NIVESTYM prefilled syringes
This Instructions for Use has been approved by the U.S. Food and Drug Administration.
Manufactured by:Hospira, Inc.,a Pfizer CompanyLake Forest, IL 60045 USAUS License No. 1974
Distributed by Pfizer Labs,division of Pfizer Inc.,New York, NY 10001 USA
For more information go to www.pfizer.com or call 1-800-438-1985.
Revised: August 2023
Instructions for UseNIVESTYM (Neye-ves-tim)(filgrastim-aafi)injectionSingle-Dose Vial
Read the Patient Information for important information you need to know about NIVESTYM before using these Instructions for Use.
Before you use a NIVESTYM vial, read this important information:
Storing your NIVESTYM vial
Keep NIVESTYM and all medicines out of the reach of children.
Using your vial
Step 1: Prepare
Step 2: Get Ready
Pull back on the plunger and draw air into the syringe that is the same amount (mL) as the dose of NIVESTYM that your healthcare provider prescribed.Important: Throw away the needle cap into the sharps disposal container. Do not recap the needle.
Step 3: Select and Prepare the Injection Site
You can use:
Step 4: Subcutaneous (under the skin) injection
Step 5: Finish
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