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ZOSYN®(piperacillin, tazobactam)
If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents.
Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.
ZOSYN® Quick Finder
Highlights
Indications and Usage
1 INDICATIONS AND USAGE
1.1 Intra-abdominal Infections
ZOSYN is indicated in adults and pediatric patients (2 months of age and older) for the treatment of...
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Dosage and Administration
2 DOSAGE AND ADMINISTRATION
2.1 Dosage in Adult Patients With Indications Other Than Nosocomial Pneumonia
The usual total daily dosage of...
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Dosage Forms and Strengths
3 DOSAGE FORMS AND STRENGTHS
ZOSYN (piperacillin and tazobactam) for Injection is a white to off-white powder in vials [all strengths of ZOSYN (piperacillin and tazobactam) for Injection are not currently being marketed]:...
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Contraindications
4 CONTRAINDICATIONS
ZOSYN is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or beta-lactamase inhibitors.
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Warnings and Precautions
5 WARNINGS AND PRECAUTIONS
5.1 Hypersensitivity Adverse Reactions
Serious and occasionally fatal hypersensitivity (anaphylactic/anaphylactoid) reactions (including...
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Adverse Reactions
6 ADVERSE REACTIONS
The following clinically significant adverse reactions are described elsewhere in the labeling:
- •
- Hypersensitivity Adverse Reactions [see Warnings...
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Drug Interactions
7 DRUG INTERACTIONS
7.1 Aminoglycosides
Piperacillin may inactivate aminoglycosides by converting them to microbiologically inert amides.
...
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Use in Specific Populations
8 USE IN SPECIFIC POPULATIONS
8.1 Pregnancy
Risk Summary
Piperacillin and...
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Overdosage
10 OVERDOSAGE
There have been postmarketing reports of overdose with piperacillin and tazobactam. The majority of those events experienced, including nausea, vomiting, and diarrhea, have also been reported with the usual...
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Description
11 DESCRIPTION
ZOSYN (piperacillin and tazobactam) for Injection is an injectable antibacterial combination product consisting of the semisynthetic antibacterial piperacillin sodium and the beta-lactamase inhibitor...
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Clinical Pharmacology
12 CLINICAL PHARMACOLOGY
12.1 Mechanism of Action
ZOSYN is an antibacterial drug [see Microbiology (12.4)].
...
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Nonclinical Toxicology
13 NONCLINICAL TOXICOLOGY
13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility
...
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References
15 REFERENCES
- 1.
- Jensen J-US, Hein L, Lundgren B, et al. BMJ Open 2012; 2:e000635. doi:10.1136.
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How Supplied/Storage and Handling
16 HOW SUPPLIED/STORAGE AND HANDLING
ZOSYN (piperacillin and tazobactam) for Injection was supplied as single-dose vials and pharmacy bulk vials in the following sizes; however all strengths of ZOSYN (piperacillin and...
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Medication Guide
17 PATIENT COUNSELING INFORMATION
Serious Hypersensitivity Reactions
Advise patients, their families, or caregivers that serious...
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Report Adverse Event
To report an adverse event related to Pfizer-BioNTech COVID-19 Vaccine (also known as COMIRNATY®, COVID-19 mRNA, Vaccine BNT162b2 or BNT162) or Pfizer COVID-19 Treatment (also known as PAXLOVID™ (nirmatrelvir tablets; ritonavir tablets)), and you are not part of a clinical trial* for this product, click the link below to submit your information:
*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.
If you cannot use the above website or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at(800) 438-1985.
You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatchor by calling
(800)-332-1088.
(800)-332-1088.