5 g Pharmacy Bulk Package Bottle
At the time of use, reconstitute by adding 100 mL of Sterile Water for Injection to the 5 g Pharmacy Bulk Package bottle of dry, sterile vancomycin powder. The resultant solution will contain vancomycin equivalent to 500 mg/10 mL (1 g/20 mL). AFTER RECONSTITUTION, FURTHER DILUTION IS REQUIRED. Reconstituted solutions of vancomycin (500 mg/10 mL) must be further diluted in at least 100 mL of a suitable infusion solution. Doses of 1 g/20 mL must be further diluted in at least 200 mL of a suitable infusion solution. The desired dose diluted in this manner should be administered by intermittent IV infusion over a period of at least 60 minutes.
10 g Pharmacy Bulk Package Bottle
At the time of use, reconstitute by adding 95 mL of Sterile Water for Injection to the 10 g Pharmacy Bulk Package bottle of dry, sterile vancomycin powder. The resultant solution will contain vancomycin equivalent to 500 mg/5 mL (1 g/10 mL). AFTER RECONSTITUTION, FURTHER DILUTION IS REQUIRED. Reconstituted solutions of vancomycin (500 mg/5 mL) must be further diluted in at least 100 mL of a suitable infusion solution. For doses of 1 g/10 mL, at least 200 mL of solution must be used. The desired dose diluted in this manner should be administered by intermittent IV infusion over a period of at least 60 minutes.
Parenteral drug products should be visually inspected for particulate matter and discoloration prior to administration, whenever solution or container permits.