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vancomycin hydrochloride, USP 5 G, PHARMACY BULK PACKAGE

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Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

vancomycin hydrochloride, USP 5 G, PHARMACY BULK PACKAGE Quick Finder

INDICATIONS AND USAGE

Vancomycin hydrochloride for injection, USP is indicated for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (β-lactam-resistant) staphylococci. It...

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DOSAGE AND ADMINISTRATION

The intent of the pharmacy bulk package for this product is for preparation of solutions for IV infusion only.

Infusion-related events are related to both the...

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CONTRAINDICATIONS

Vancomycin hydrochloride for injection is contraindicated in patients with known hypersensitivity to this antibiotic.

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WARNINGS

Infusion Reactions

Rapid bolus administration (e.g., over several minutes) may be associated with exaggerated hypotension, including shock and rarely cardiac...

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ADVERSE REACTIONS

Infusion-Related Events

During or soon after rapid infusion of vancomycin hydrochloride for injection, patients may develop anaphylactoid...

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OVERDOSAGE

Supportive care is advised, with maintenance of glomerular filtration. Vancomycin is poorly removed by dialysis. Hemofiltration and hemoperfusion with polysulfone resin have been reported to result in increased...

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DESCRIPTION

Vancomycin hydrochloride for injection, USP, is a lyophilized powder, for preparing intravenous (IV) infusions, in Pharmacy Bulk Package bottles containing the equivalent of 5 g or 10 g vancomycin base. 500 mg of...

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CLINICAL PHARMACOLOGY

Vancomycin is poorly absorbed after oral administration.

In subjects with normal kidney function, multiple intravenous dosing of 1 g of vancomycin (15 mg/kg) infused over 60 minutes produces mean...

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ANIMAL PHARMACOLOGY

In animal studies, hypotension and bradycardia occurred in dogs receiving an intravenous infusion of vancomycin hydrochloride 25 mg/kg, at a concentration of 25 mg/mL and an infusion rate of 13.3 mL/min...

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REFERENCES

1.
Moellering RC, Krogstad DJ, Greenblatt DJ: Vancomycin therapy in patients with impaired renal function: A nomogram for dosage. Ann Inter Med 1981;94:343.

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HOW SUPPLIED/STORAGE AND HANDLING

Vancomycin Hydrochloride for Injection, USP is supplied as follows:

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PHARMACY BULK PACKAGE – NOT FOR DIRECT INFUSION

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