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TIGAN®(trimethobenzamide HCl)

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Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

TIGAN® Quick Finder

HIGHLIGHTS OF PRESCRIBING INFORMATION

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1 INDICATIONS AND USAGE

Tigan is indicated in adults for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

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2 DOSAGE AND ADMINISTRATION

2.1 Recommended Adult Dosage

The recommended adult dosage is 300 mg orally three or four times daily. Select the lowest effective daily...

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3 DOSAGE FORMS AND STRENGTHS

Capsules: 300 mg trimethobenzamide hydrochloride; the capsule has an opaque purple cap marked "Tigan" and an opaque purple body marked "M079".

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4 CONTRAINDICATIONS

Tigan is contraindicated in patients with known hypersensitivity to trimethobenzamide [see Adverse Reactions (6)].

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5 WARNINGS AND PRECAUTIONS

5.1 Acute Dystonic Reactions and Other Extrapyramidal Symptoms (EPS)

Extrapyramidal symptoms (EPS), manifested primarily as acute dystonic...

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6 ADVERSE REACTIONS

The following adverse reactions from voluntary reports or clinical studies have been reported with trimethobenzamide. Because many of these reactions were reported voluntarily from a population of...

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7 DRUG INTERACTIONS

7.1 Alcohol

Alcohol may increase the CNS depressant effects of Tigan and may cause drowsiness [see

7.2 Other Drugs that...

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8 USE IN SPECIFIC POPULATIONS

8.1 Pregnancy

Risk Summary

The limited available...

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11 DESCRIPTION

Chemically, trimethobenzamide hydrochloride is N-[p-[2-(dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide monohydrochloride. It has a molecular weight of 424.93 and the...

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12 CLINICAL PHARMACOLOGY

12.1 Mechanism of Action

The mechanism of action of trimethobenzamide as determined in animals is obscure, but may involve the chemoreceptor...

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16 HOW SUPPLIED/STORAGE AND HANDLING

Tigan is available as a capsule for oral use with an opaque purple cap marked "Tigan" and an opaque purple body marked "M079". Each capsule contains 300 mg of trimethobenzamide...

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17 PATIENT COUNSELING INFORMATION

Inform patients that Tigan can cause serious adverse reactions. Instruct patients to discontinue Tigan and contact a healthcare provider immediately if the following serious reactions occur...

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This product's label may have been updated. For full prescribing information, please visit www.pfizer.com.

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