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THROMBIN-JMI®References (thrombin, topical, bovine origin)


Morse DC, Silva E, Bartrom J, et al: Improved bleeding scores using Gelfoam Powder with incremental concentrations of bovine thrombin in a swine liver lesion model. J Throm Thrombolysis. 2016;42(3):352–359.
Chapman WC, Singla N, Genyk Y, et al: A Phase 3, Randomized, Double-Blind Comparative Study of the Efficacy and Safety of Topical Recombinant Human Thrombin and Bovine Thrombin in Surgical Hemostasis. J Am Coll Surg. 2007;205:256–265.
Doria C, Fischer CP, Wood CG, et al: Phase 3, randomized, double-blind study of plasma-derived human thrombin versus bovine thrombin in achieving hemostasis in patients undergoing surgery. Curr Med Res Opin. 2008;24(3):785–794.
Driver VR, Hanft J, Fylling CP, et al: A Prospective, Randomized, Controlled Trial of Autologous Platelet-Rich Plasma Gel for the Treatment of Diabetic Foot Ulcers. Ostomy/Wound Management. 2006;52(6):68–87.
Minkowitz H, Navarro-Puerto J, Lakshman S, et al: Prospective, Randomized, Phase II, Non-Inferiority Study to Evaluate the Safety and Efficacy of Topical Thrombin (Human) Grifols as Adjunct to Hemostasis During Vascular, Hepatic, Soft Tissue, and Spinal Open Surgery. J Am Coll Surg. 2019;229(5):497–507.
Paterson CA, Pixton GC, Proskin HM, et al: Immune responses associated with perioperative exposure and reexposure to topical bovine thrombin do not impair hemostasis. Clin Appl Thromb Hemost. 2011;17(6):620–632.
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