Too rapid administration and/or excessive amounts of tromethamine may cause alkalosis, hypoglycemia, overhydration or solute overload. In the event of overdosage, discontinue the infusion, evaluate the patient and institute appropriate countermeasures (see WARNINGS, PRECAUTIONS and ADVERSE REACTIONS).
The LD50 values for the acute intravenous toxicity of THAM are influenced by the rate of infusion of the dose administered.
Intravenous LD50 Mice = 3,500 mg/kg
Intravenous LD50 Rats = 2,300 mg/kg