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THAM (tromethamine injection)

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Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

THAM Quick Finder

INDICATIONS AND USAGE

Tham Solution (tromethamine injection) is indicated for the prevention and correction of metabolic acidosis. In the following conditions it may...

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DOSAGE AND ADMINISTRATION

Tham Solution (tromethamine injection) is administered by slow intravenous infusion, by addition to pump-oxygenator ACD blood or other priming...

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CONTRAINDICATIONS

Tham Solution (tromethamine injection) is contraindicated in uremia and anuria. In neonates it is also contraindicated in chronic respiratory acidosis...

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WARNINGS

  1. Large doses of Tham Solution may depress ventilation, as a result of increased blood pH and reduced CO2...

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ADVERSE REACTIONS

Generally, side effects have been infrequent.

Respiratory: Although the incidence of ventilatory depression is...

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OVERDOSAGE

Too rapid administration and/or excessive amounts of tromethamine may cause alkalosis, hypoglycemia, overhydration or solute overload. In the event of...

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DESCRIPTION

Tham Solution (tromethamine injection) is a sterile, non-pyrogenic 0.3 M solution of tromethamine, adjusted to a pH of approximately 8.6 with glacial acetic acid. It is administered by intravenous injection, by...

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CLINICAL PHARMACOLOGY

When administered intravenously as a 0.3 M solution, tromethamine act as a proton acceptor and prevents or corrects acidosis by actively binding hydrogen ions (H+). It binds not...

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HOW SUPPLIED

Tham Solution (tromethamine injection) is available as:

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For the Prevention and Correction of Severe Metabolic Acidosis

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