Tazicef may be given intravenously. Intra-arterial administration should be avoided (see PRECAUTIONS).
Intravenous Administration
The IV route is preferable for patients with bacterial septicemia, bacterial meningitis, peritonitis, or other severe or life-threatening infections, or for patients who may be poor risks because of lowered resistance resulting from such debilitating conditions as malnutrition, trauma, surgery, diabetes, heart failure, or malignancy, particularly if shock is present or pending.
Intermittent IV infusion with a Y-type administration set can be accomplished with compatible solutions. However, during infusion of a solution containing ceftazidime, it is desirable to discontinue the other solution.
ADD-Vantage vials are to be constituted only with 50 or 100 mL of 5% Dextrose Injection, 0.9% Sodium Chloride Injection, or 50 mL of 0.45% Sodium Chloride Injection in ADD-Vantage diluent (see Instructions for Use). ADD-Vantage vials should be reconstituted only when it is certain that the patient is ready to receive the drug. Tazicef in ADD-Vantage vials is stable for 24 hours at room temperature.
Note: Tazicef (ceftazidime for injection, USP) in the ADD-Vantage vial is intended to be administered as a single-dose intravenous infusion with the ADD-Vantage flexible diluent container.
All vials of Tazicef as supplied are under reduced pressure. When Tazicef is dissolved, carbon dioxide is released and a positive pressure develops. For ease of use please follow the recommended techniques of constitution described on the instructions for use section of this insert.
Solutions of Tazicef, like those of most beta-lactam antibacterial drugs, should not be added to solutions of aminoglycoside antibacterial drugs because of potential interaction.
However, if concurrent therapy with Tazicef and an aminoglycoside is indicated, each of these antibacterial drugs can be administered separately to the same patient.