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TAPAZOLE®(methimazole)

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Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

TAPAZOLE® Quick Finder

INDICATIONS AND USAGE

TAPAZOLE is indicated:

  • In patients with Graves' disease with hyperthyroidism or toxic multinodular goiter for whom surgery or radioactive iodine therapy is not an appropriate...
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DOSAGE AND ADMINISTRATION

TAPAZOLE is administered orally. The total daily dosage is usually given in 3 divided doses at approximately 8-hour intervals.

Adult

...
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CONTRAINDICATIONS

TAPAZOLE is contraindicated in the presence of hypersensitivity to the drug or any of the other product components.

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WARNINGS

First Trimester Use of Methimazole and Congenital Malformations

Methimazole crosses the placental membranes and can cause fetal harm, when administered in the...

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ADVERSE REACTIONS

Major adverse reactions (which occur with much less frequency than the minor adverse reactions) include inhibition of myelopoiesis (agranulocytosis, granulocytopenia, thrombocytopenia, and aplastic anemia...

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OVERDOSAGE

Signs and Symptoms

Symptoms may include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (...

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DESCRIPTION

Methimazole (1-methylimidazole-2-thiol) is a white, crystalline substance that is freely soluble in water. It differs chemically from the drugs of the thiouracil series primarily because it has a 5- instead of a 6...

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CLINICAL PHARMACOLOGY

Methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. The drug does not inactivate existing thyroxine and tri-iodothyronine that are stored in...

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HOW SUPPLIED

TAPAZOLE Tablets are available in:

The 5-mg tablets are round, white to off-white, bisected on one side and the other side debossed with "J94".

They are available as follows:

Bottles of 100...

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Logo

Manufactured by:
Alcami Corporation,
1726 North 23rd St.,
Wilmington,
NC...

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