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TALZENNA Drug Interactions (talazoparib)

7 DRUG INTERACTIONS

7.1 Effect of Other Drugs on TALZENNA

Effect of P-gp Inhibitors

Coadministration with P-gp inhibitors may increase talazoparib exposure.

In patients with advanced solid tumors, coadministration of a P-gp inhibitor (itraconazole) increased talazoparib plasma exposure by 56%. In the clinical studies, coadministration with P-gp inhibitors including amiodarone, carvedilol, clarithromycin, itraconazole, and verapamil resulted in an approximate 45% increase in talazoparib exposure and an increase in the rate of TALZENNA dose reduction. If coadministration of TALZENNA with these P-gp inhibitors cannot be avoided, reduce the TALZENNA dose [see Dosage and Administration (2.5)]. When the P-gp inhibitor is discontinued, increase the TALZENNA dose (after 3–5 half-lives of the inhibitor) to the dose used prior to the initiation of the P-gp inhibitor [see Dosage and Administration (2.5), Clinical Pharmacology (12.3)].

When coadministering TALZENNA with P-gp inhibitors not listed above, monitor patients for potential increased adverse reactions [see Dosage and Administration (2.5), Clinical Pharmacology (12.3)].

Effect of BCRP inhibitors

Coadministration with BCRP inhibitors may increase talazoparib exposure. If coadministration cannot be avoided, monitor patients for potential increased adverse reactions when coadministering [see Clinical Pharmacology (12.3)].

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