DESCRIPTION
SOLU-CORTEF Sterile Powder is an anti-inflammatory glucocorticoid that contains hydrocortisone sodium succinate as the active ingredient. SOLU-CORTEF Sterile Powder is available in several packages for intravenous or intramuscular administration.
100 mg Plain
Vials containing hydrocortisone sodium succinate equivalent to 100 mg hydrocortisone, 0.8 mg monobasic sodium phosphate anhydrous, 8.73 mg dibasic sodium phosphate dried. SOLU-CORTEF 100 mg plain does not contain diluent (see DOSAGE AND ADMINISTRATION, Preparation of Solutions).
| 100 mg ACT-O-VIAL | 250 mg ACT-O-VIAL | 500 mg ACT-O-VIAL | 1000 mg ACT-O-VIAL | |
|---|---|---|---|---|
| Each 2 mL contains (when mixed): | Each 2 mL contains (when mixed): | Each 4 mL contains (when mixed): | Each 8 mL contains (when mixed): | |
| Hydrocortisone sodium succinate | equiv. to 100 mg Hydrocortisone | equiv. to 250 mg Hydrocortisone | equiv. to 500 mg Hydrocortisone | equiv. to 1000 mg Hydrocortisone |
| Monobasic sodium phosphate anhydrous | 0.8 mg | 2 mg | 4 mg | 8 mg |
| Dibasic sodium phosphate dried | 8.73 mg | 21.8 mg | 44 mg | 87.32 mg |
The diluent, as part of the packaging presentation for the ACT-O-VIAL® system, is comprised of Water for Injection only, and does not contain any preservative.
When necessary, the pH of each formula was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7 to 8.
The chemical name for hydrocortisone sodium succinate is pregn-4-ene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, monosodium salt, (11β)- and its molecular weight is 484.52.
The structural formula is represented below:
Hydrocortisone sodium succinate is a white or nearly white, odorless, hygroscopic amorphous solid. It is very soluble in water and in alcohol, very slightly soluble in acetone, and insoluble in chloroform.