The most frequent adverse reactions observed with the use of dinoprostone for abortion are related to its contractile effect on smooth muscle.
In the patients studied, approximately two-thirds experienced vomiting, one-half temperature elevations, two-fifths diarrhea, one-third some nausea, one-tenth headache, and one-tenth shivering and chills.
In addition, approximately one-tenth of the patients studied exhibited transient diastolic blood pressure decreases of greater than 20 mmHg.
Two cases of myocardial infarction following the use of dinoprostone have been reported in patients with a history of cardiovascular disease.
It is not known whether these events were related to the administration of dinoprostone.
Adverse effects in decreasing order of their frequency, observed with the use of dinoprostone, not all of which are clearly drug related include:
Chills or shivering
Joint inflammation or pain new or exacerbated
Flushing or hot flashes
Syncope or fainting sensation
Vaginitis or vulvitis
Muscular cramp or pain
Tightness in chest
|Nocturnal leg cramps