4 CONTRAINDICATIONS
PREMARIN therapy is contraindicated in individuals with any of the following conditions:
- Undiagnosed abnormal genital bleeding
- Known, suspected, or history of breast cancer except in appropriately selected patients being treated for metastatic disease
- Known or suspected estrogen-dependent neoplasia
- Active DVT, PE, or a history of these conditions
- Active arterial thromboembolic disease (for example stroke and MI), or a history of these conditions
- Known anaphylactic reaction or angioedema with Premarin
- Known liver impairment or disease
- Known protein C, protein S or antithrombin deficiency, or other known thrombophilic disorders.
- Known or suspected pregnancy