4 CONTRAINDICATIONS
PREMARIN Vaginal Cream therapy should not be used in women with any of the following conditions:
- Undiagnosed abnormal genital bleeding
- Known, suspected, or history of breast cancer
- Known or suspected estrogen-dependent neoplasia
- Active DVT, PE, or a history of these conditions
- Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
- Known anaphylactic reaction or angioedema to PREMARIN Vaginal Cream
- Known liver dysfunction or disease
- Known protein C, protein S or antithrombin deficiency or other known thrombophilic disorders
- Known or suspected pregnancy