PREMARIN^® INTRAVENOUS Contraindications (conjugated estrogens)

CONTRAINDICATIONS

Premarin Intravenous therapy should not be used in individuals with any of the following conditions:

1. Undiagnosed abnormal genital bleeding.
2. Known, suspected, or history of breast cancer.
3. Known or suspected estrogen-dependent neoplasia.
4. Active DVT, PE or a history of these conditions.
5. Active arterial thromboembolic disease (for example, stroke and MI) or a history of these conditions.
6. Known anaphylactic reaction and angioedema to Premarin Intravenous therapy.
7. Known liver dysfunction or disease.
8. Known protein C, protein S, or antithrombin deficiency or other known thrombophilic disorders.
9. Known or suspected pregnancy.