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PLEGISOL (cardioplegic solution for cardiac perfusion)

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PLEGISOL Quick Finder

INDICATIONS AND USAGE

Plegisol (Cardioplegic Solution) when suitably buffered in combination with ischemia and hypothermia is used to induce cardiac arrest during open heart surgery.

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DOSAGE AND ADMINISTRATION

The following information is suggested as a guide and is subject to variation according to the preference and experience of the surgeon.

It is required that 10 mL (840 mg) of 8.4% Sodium...

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CONTRAINDICATIONS

Plegisol must not be administered without the addition of 8.4% Sodium Bicarbonate Injection, USP, Hospira List 4900.

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WARNINGS

This solution should be used only by those trained to perform open heart surgery. This solution is intended only for use during cardiopulmonary bypass when the coronary circulation is isolated from the systemic...

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ADVERSE REACTIONS

Intraoperative and perioperative potential hazards of open heart surgery include myocardial infarction, electrocardiographic abnormalities, and arrhythmias, including ventricular fibrillation. Spontaneous...

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OVERDOSAGE

Overzealous instillation of the solution may result in unnecessary dilatation of the myocardial vasculature and leakage into the perivascular myocardium, possibly causing tissue edema (See ...

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DESCRIPTION

Plegisol (Cardioplegic Solution) is a sterile, nonpyrogenic, essentially isotonic, formulation of electrolytes in water for injection. It is a "core solution" intended for use ...

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CLINICAL PHARMACOLOGY

Plegisol with added sodium bicarbonate when cooled and instilled into the coronary artery vasculature, causes prompt arrest of cardiac electromechanical activity, combats intracellular ion losses and...

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HOW SUPPLIED

Plegisol® (Cardioplegic Solution) is supplied (without sodium bicarbonate) as follows:

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CARDIOPLEGIC SOLUTION FOR CARDIAC PERFUSION

NOT FOR...

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