INDICATIONS AND USAGE
Plegisol (Cardioplegic Solution) when suitably buffered in combination with ischemia and hypothermia is used to induce cardiac arrest during open heart surgery.
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PLEGISOL (cardioplegic solution for cardiac perfusion)
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Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.
PLEGISOL Quick Finder
Dosage and Administration
DOSAGE AND ADMINISTRATION
The following information is suggested as a guide and is subject to variation according to the preference and experience of the surgeon.
It is required that 10 mL (840 mg) of 8.4% Sodium...
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Contraindications
CONTRAINDICATIONS
Plegisol must not be administered without the addition of 8.4% Sodium Bicarbonate Injection, USP, Hospira List 4900.
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Warnings and Precautions
WARNINGS
This solution should be used only by those trained to perform open heart surgery. This solution is intended only for use during cardiopulmonary bypass when the coronary circulation is isolated from the systemic...
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Adverse Reactions
ADVERSE REACTIONS
Intraoperative and perioperative potential hazards of open heart surgery include myocardial infarction, electrocardiographic abnormalities, and arrhythmias, including ventricular fibrillation. Spontaneous...
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Overdosage
OVERDOSAGE
Overzealous instillation of the solution may result in unnecessary dilatation of the myocardial vasculature and leakage into the perivascular myocardium, possibly causing tissue edema (See ...
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Description
DESCRIPTION
Plegisol (Cardioplegic Solution) is a sterile, nonpyrogenic, essentially isotonic, formulation of electrolytes in water for injection. It is a "core solution" intended for use ...
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Clinical Pharmacology
CLINICAL PHARMACOLOGY
Plegisol with added sodium bicarbonate when cooled and instilled into the coronary artery vasculature, causes prompt arrest of cardiac electromechanical activity, combats intracellular ion losses and...
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How Supplied/Storage and Handling
HOW SUPPLIED
Plegisol® (Cardioplegic Solution) is supplied (without sodium bicarbonate) as follows:
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