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piperacillin tazobactam for injection - VIAL

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piperacillin tazobactam for injection - VIAL Quick Finder

HIGHLIGHTS OF PRESCRIBING INFORMATION

These highlights do not include all the...
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1 INDICATIONS AND USAGE

1.1 Intra-abdominal Infections

Piperacillin and tazobactam for injection is indicated in adults and pediatric patients (2 months of age and...

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2 DOSAGE AND ADMINISTRATION

2.2 Dosage in Adult Patients with Indications Other Than Nosocomial Pneumonia

The usual total daily dosage of piperacillin and tazobactam...

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3 DOSAGE FORMS AND STRENGTHS

Piperacillin and tazobactam for injection, USP is supplied as a white to yellowish powder in vials of the following sizes:

Each piperacillin and tazobactam for injection, USP 2.25 g vial...

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4 CONTRAINDICATIONS

Piperacillin and tazobactam for injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or beta-lactamase inhibitors.

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5 WARNINGS AND PRECAUTIONS

5.1 Hypersensitivity Adverse Reactions

Serious and occasionally fatal hypersensitivity (anaphylactic/anaphylactoid) reactions (including...

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6 ADVERSE REACTIONS

6.1 Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the...

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7 DRUG INTERACTIONS

7.1 Aminoglycosides

Piperacillin may inactivate aminoglycosides by converting them to microbiologically inert amides.

...

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8 USE IN SPECIFIC POPULATIONS

8.1 Pregnancy

Risk Summary

Piperacillin and tazobactam cross the placenta...

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10 OVERDOSAGE

There have been post-marketing reports of overdose with piperacillin/tazobactam. The majority of those events experienced, including nausea, vomiting, and diarrhea, have also been reported with the usual...

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11 DESCRIPTION

Piperacillin and tazobactam for injection, USP is an injectable antibacterial combination products consisting of the semisynthetic antibacterial piperacillin sodium and the beta-lactamase inhibitor tazobactam...

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12 CLINICAL PHARMACOLOGY

12.1 Mechanism of Action

Piperacillin and tazobactam for injection is an antibacterial drug [...

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13 NONCLINICAL TOXICOLOGY

13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility

Carcinogenesis

Long-...

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15 REFERENCES

1.
Jensen J-US, Hein L, Lundgren B, et al. BMJ Open 2012; 2:e000635. doi:10.1136.
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16 HOW SUPPLIED/STORAGE AND HANDLING

Piperacillin and tazobactam for injection, USP is supplied as single-dose vials in the following sizes:

Each piperacillin and tazobactam for injection, USP 2.25 g vial provides...

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17 PATIENT COUNSELING INFORMATION

Serious Hypersensitivity Reactions

Advise patients, their families, or caregivers that serious hypersensitivity reactions, including serious allergic...

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