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PENICILLIN G PROCAINE Adverse Reactions

ADVERSE REACTIONS

The following adverse reactions have been reported with parenteral penicillin G (the active moiety in Penicillin G Procaine)

Allergic Reactions

Penicillin is a substance of low toxicity but does possess a significant index of sensitization. The following hypersensitivity reactions associated with use of penicillin have been reported: Skin rashes, ranging from maculopapular eruptions to exfoliative dermatitis; urticaria; serum-sickness like reactions, including chills, fever, edema, arthralgia, and prostration. Severe and often fatal anaphylaxis has been reported: severe cutaneous adverse reactions (SCAR), such as toxic epidermal necrolysis (TEN) and acute generalized exanthematous pustulosis (AGEP) (see WARNINGS). As with other treatments for syphilis, the Jarisch-Herxheimer reaction has been reported.

Procaine toxicity manifestations and hypersensitivity reactions have been reported (see WARNINGS and PRECAUTIONS).

The following adverse events have been temporally associated with parenteral administration of Penicillin G Procaine (a component of Penicillin G Procaine)

Body as a Whole

Nicolau syndrome.

Gastrointestinal

Pseudomembranous colitis has been reported with the use of penicillin G. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment (see WARNINGS).

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