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ZOSYN®(piperacillin, tazobactam)
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ZOSYN® Quick Finder
1 INDICATIONS AND USAGE
1.1 Intra-abdominal Infections
ZOSYN is indicated in adults and pediatric patients (2 months of age and older) for the treatment of...
2 DOSAGE AND ADMINISTRATION
2.1 Important Administration Instructions
If a dose of ZOSYN is required that does not equal 2.25 g, 3.375 g, or 4.5 g, ZOSYN injection...
3 DOSAGE FORMS AND STRENGTHS
ZOSYN® (piperacillin and tazobactam) Injection is supplied in GALAXY Containers as a frozen, iso-osmotic, sterile, non-pyrogenic solution in single-dose plastic...
4 CONTRAINDICATIONS
ZOSYN is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or beta-lactamase inhibitors.
5 WARNINGS AND PRECAUTIONS
5.1 Hypersensitivity Adverse Reactions
Serious and occasionally fatal hypersensitivity (anaphylactic/anaphylactoid) reactions (including...
7 DRUG INTERACTIONS
7.1 Aminoglycosides
Piperacillin may inactivate aminoglycosides by converting them to microbiologically inert amides.
...8 USE IN SPECIFIC POPULATIONS
8.1 Pregnancy
Risk Summary
Piperacillin and tazobactam...
10 OVERDOSAGE
There have been postmarketing reports of overdose with piperacillin/tazobactam. The majority of those events experienced, including nausea, vomiting, and diarrhea, have also been reported with the usual...
11 DESCRIPTION
ZOSYN (piperacillin and tazobactam) for Injection and ZOSYN (piperacillin and tazobactam) Injection are injectable antibacterial combination products consisting of the semisynthetic antibacterial piperacillin...
12 CLINICAL PHARMACOLOGY
12.1 Mechanism of Action
ZOSYN is an antibacterial drug [see Microbiology (12.4)].
...13 NONCLINICAL TOXICOLOGY
13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility
...
15 REFERENCES
- Jensen J-US, Hein L, Lundgren B, et al. BMJ Open 2012; 2:e000635. doi:10.1136.
16 HOW SUPPLIED/STORAGE AND HANDLING
ZOSYN (piperacillin and tazobactam) Injection in GALAXY Containers are supplied as a frozen, iso-osmotic, sterile, nonpyrogenic solution in single-dose plastic containers as follows:
...17 PATIENT COUNSELING INFORMATION
Serious Hypersensitivity Reactions
Advise patients, their families, or caregivers that serious...
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