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zoledronic acid for injection 4 MG VIAL

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zoledronic acid for injection 4 MG VIAL Quick Finder

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17 PATIENT COUNSELING INFORMATION

Drugs With Same Active Ingredient or in the Same Drug Class

Inform patients not to take Reclast or other bisphosphonates during the course of their zoledronic acid injection therapy [see

Renal Impairment

  • Instruct patients to tell their doctor if they have kidney problems before being given zoledronic acid injection.
  • Inform patients of the importance of getting their blood tests (serum creatinine) during the course of their zoledronic acid injection therapy [see

    Osteonecrosis of the Jaw (ONJ)

    • Advise patients to have a dental examination prior to treatment with zoledronic acid injection and to avoid invasive dental procedures during treatment.
    • Inform patients of the importance of good dental hygiene, routine dental care, and regular dental check-ups.
    • Advise patients to immediately tell their doctor about any oral symptoms such as loosening of a tooth, pain, swelling, or non-healing of sores or discharge during treatment with zoledronic acid injection [see

      Musculoskeletal Pain

      Advise patients to immediately tell their doctor about any severe bone, joint, and/or muscle pain [see

      Atypical Subtrochanteric and Diaphyseal Femoral Fracture

      Advise patients to report any thigh, hip, or groin pain. It is unknown whether the risk of atypical femur fracture continues after stopping therapy [see

      Patients With Asthma

      There have been reports of bronchoconstriction in aspirin-sensitive patients receiving bisphosphonates, including zoledronic acid. Before being given zoledronic acid, instruct patients to tell their doctor if they are aspirin-sensitive [see

      Hypocalcemia

      Advise patients with multiple myeloma and bone metastasis of solid tumors to take an oral calcium supplement of 500 mg and a multiple vitamin containing 400 international units of vitamin D daily [see

      Embryo-Fetal Toxicity

      • Zoledronic acid injection should not be given if the patient is pregnant or plans to become pregnant. Inform female patients of the risk to a fetus and potential loss of the pregnancy [see

        Lactation

        Advise lactating women not to breastfeed during and after treatment with zoledronic acid [see

        Common Adverse Reactions

        Advise patients that the most common side effects of zoledronic acid injection are nausea, fatigue, anemia, bone pain, constipation, fever, vomiting, and dyspnea.

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