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TRECATOR®(ethionamide)

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TRECATOR® Quick Finder

INDICATIONS AND USAGE

Trecator is primarily indicated for the treatment of active tuberculosis in patients with M. tuberculosis resistant to isoniazid or rifampin, or when there is intolerance on...

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DOSAGE AND ADMINISTRATION

In the treatment of tuberculosis, a major cause of the emergence of drug-resistant organisms, and thus treatment failure, is patient nonadherence to prescribed treatment. Treatment failure and drug-...

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CONTRAINDICATIONS

Ethionamide is contraindicated in patients with severe hepatic impairment and in patients who are hypersensitive to the drug.

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WARNINGS

The use of Trecator alone in the treatment of tuberculosis results in rapid development of resistance. It is essential, therefore, to give a suitable companion drug or drugs, the choice being based on the results of...

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ADVERSE REACTIONS

Gastrointestinal

The most common side effects of ethionamide are gastrointestinal disturbances including nausea, vomiting, diarrhea, abdominal pain,...

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OVERDOSAGE

No specific information is available on the treatment of overdosage with Trecator. If it should occur, standard procedures to evacuate gastric contents and to support vital functions should be employed.

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DESCRIPTION

Trecator® (ethionamide tablets, USP) is used in the treatment of tuberculosis. The chemical name for ethionamide is 2-ethylthioisonicotinamide with the following structural formula:

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CLINICAL PHARMACOLOGY

Absorption

Ethionamide is essentially completely absorbed following oral administration and is not subjected to any appreciable first pass...

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REFERENCES

  1. Feigin, R.D., and Cherry, J.D.: Textbook of Pediatric Infectious Diseases, 2nd Edition. Philadelphia, W.B. Saunders Co., 1987, pp. 1371–1372.
  2. Nelson, W.E., Behrman, R.E., Vaughan, V.C. (eds.): Nelson Textbook of...
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HOW SUPPLIED

Trecator (ethionamide tablets, USP) are supplied in bottles of 100 tablets as follows:

250 mg, orange film-coated tablet marked "W" on one side and "4117" on reverse side, NDC 0008-4117-01.

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To reduce the development of drug-resistant bacteria and maintain the effectiveness of Trecator and other antibacterial drugs, Trecator should be used only to treat infections...

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