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QUINAPRIL Hydrochloride AND HYDROCHLOROTHIAZIDE Tablets (GREENSTONE LLC)

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QUINAPRIL Hydrochloride AND HYDROCHLOROTHIAZIDE Tablets (GREENSTONE LLC) Quick Finder

WARNING: FETAL TOXICITY

  • When pregnancy is detected, discontinue quinapril and hydrochlorothiazide tablets as soon as possible.
  • Drugs that act directly on the renin-...
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INDICATIONS AND USAGE

Hypertension

Quinapril and hydrochlorothiazide tablets are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood...

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DOSAGE AND ADMINISTRATION

As individual monotherapy, quinapril is an effective treatment of hypertension in once-daily doses of 10 to 80 mg and hydrochlorothiazide is effective in doses of 12.5 to 50 mg. In clinical trials...

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CONTRAINDICATIONS

Quinapril and hydrochlorothiazide tablets are contraindicated in patients who are hypersensitive to quinapril or hydrochlorothiazide and in patients with a history of angioedema related to previous...

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WARNINGS

Anaphylactoid and Possibly Related Reactions

Presumably because angiotensin converting inhibitors affect the metabolism of eicosanoids and polypeptides,...

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ADVERSE REACTIONS

Quinapril and hydrochlorothiazide tablets have been evaluated for safety in 1571 patients in controlled and uncontrolled studies. Of these, 498 were given quinapril plus hydrochlorothiazide for at least 1...

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OVERDOSAGE

No specific information is available on the treatment of overdosage with quinapril and hydrochlorothiazide tablets or quinapril monotherapy; treatment should be symptomatic and supportive. Therapy with quinapril...

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DESCRIPTION

Quinapril and hydrochlorothiazide tablets are fixed-combination tablets that combine an angiotensin-converting enzyme (ACE) inhibitor, quinapril hydrochloride, and a thiazide diuretic, hydrochlorothiazide.

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CLINICAL PHARMACOLOGY

Mechanism of Action

The principal metabolite of quinapril, quinaprilat, is an inhibitor of ACE activity in human subjects and animals. ACE is...

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HOW SUPPLIED

Quinapril and hydrochlorothiazide tablets are available in three different strengths:

10/12.5 tablets: pink, scored elliptical, biconvex, film-coated tablets coded "G 222" on one...

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LAB-0316-20.0
Revised March 2021

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