WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER and PROBABLE DEMENTIA
Estrogen-Alone Therapy
Endometrial...
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PREMARIN® INTRAVENOUS (conjugated estrogens)
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PREMARIN® INTRAVENOUS Quick Finder
Indications and Usage
INDICATIONS AND USAGE
Premarin Intravenous (conjugated estrogens, USP) for injection is indicated in the treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology.
Premarin...
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Dosage and Administration
DOSAGE AND ADMINISTRATION
For treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology:
One 25 mg injection, intravenously or intramuscularly. Intravenous use is preferred...
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Contraindications
CONTRAINDICATIONS
Premarin Intravenous therapy should not be used in individuals with any of the following conditions:
- Undiagnosed abnormal genital bleeding.
- Known, suspected, or history of breast cancer...
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Warnings and Precautions
WARNINGS
See BOXED WARNINGS.
Premarin Intravenous for injection is indicated for short-term use. However, warnings, precautions and adverse reactions associated with oral...
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Adverse Reactions
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Overdosage
OVERDOSAGE
Overdosage of estrogen may cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding may occur in women. Treatment of overdose consists of discontinuation of...
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Description
DESCRIPTION
Premarin Intravenous (conjugated estrogens, USP) for injection contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates...
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Clinical Pharmacology
CLINICAL PHARMACOLOGY
Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a...
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Clinical Studies
CLINICAL STUDIES
Women's Health Initiative Studies
The Women's Health Initiative (WHI) enrolled approximately 27,000 predominantly healthy postmenopausal women in two...
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How Supplied/Storage and Handling
HOW SUPPLIED
NDC 0046-0749-05–Each package provides one single-dose vial containing 25 mg/vial of conjugated estrogens, USP, for injection (also lactose 200 mg, sodium citrate 12.2 mg, and simethicone 0.2 mg). The pH is...
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Medication Guide
PATIENT INFORMATION
Premarin Intravenous (conjugated estrogens, USP) for injection
Read this PATIENT INFORMATION which describes the benefit and major risks of your treatment, as well as how...
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Resources
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