Septicemia, empyema, pneumonia, pericarditis, endocarditis, meningitis | | Streptococcus pyogenes (group A β-hemolytic streptococcus), other β-hemolytic streptococci including groups C, H, G, L and M, Streptococcus pneumoniae and Staphylococcus species (non-penicillinase producing strains)
|
Anthrax | | Bacillus anthracis
|
Actinomycosis (cervico-facial disease and thoracic and abdominal disease) | | Actinomyces israelii
|
Botulism (adjunctive therapy to antitoxin), gas gangrene, and tetanus (adjunctive therapy to human tetanus immune globulin)
| | Clostridium species |
Diphtheria (adjunctive therapy to antitoxin and prevention of the carrier state)
| | Corynebacterium diphtheriae |
Erysipelothrix endocarditis
| | Erysipelothrix rhusiopathiae |
Fusospirochetosis (severe infections of the oropharynx [Vincent's], lower respiratory tract and genital area)
| | Fusobacterium species and spirochetes |
Listeria infections including meningitis and endocarditis
| | Listeria monocytogenes |
Pasteurella infections including bacteremia and meningitis
| | Pasteurella multocida |
Haverhill fever | | Streptobacillus moniliformis
|
Rat bite fever | | Spirillum minus or Streptobacillus moniliformis |
Disseminated gonococcal infections | | Neisseria gonorrhoeae (Penicillin-susceptible)
|
Syphilis (congenital and neurosyphilis) | | Treponema pallidum
|
Meningococcal meningitis and/or septicemia | | Neisseria meningitidis
|
Gram-negative bacillary infections (bacteremias) Penicillin G is not the drug of choice in the treatment of Gram-negative bacillary infections. | | Gram-negative bacillary organisms (i.e. Enterobacteriaceae) |