WARNING: SERIOUS AND LIFE-THREATENING RISKS FROM USE OF NALBUPHINE HYDROCHLORIDE INJECTION
Life-Threatening Respiratory Depression
Serious, life-threatening, or fatal...
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nalbuphine hydrochloride injection
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nalbuphine hydrochloride injection Quick Finder
Indications and Usage
INDICATIONS AND USAGE
Nalbuphine Hydrochloride Injection is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Nalbuphine Hydrochloride...
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Dosage and Administration
DOSAGE AND ADMINISTRATION
Important Dosage and Administration Instructions
Nalbuphine Hydrochloride Injection should be administered as a supplement to general...
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Warnings and Precautions
WARNINGS
Life-Threatening Respiratory Depression
Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used...
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Adverse Reactions
ADVERSE REACTIONS
The following serious adverse reactions are described, or described in greater detail, in other sections:
- •
- Opioid-Induced Hyperalgesia and Allodynia [see ...
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Drug Abuse and Dependence
DRUG ABUSE AND DEPENDENCE
Abuse
Nalbuphine Hydrochloride Injection contains nalbuphine, a substance which is subject to misuse and abuse, which can lead to the ...
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Overdosage
OVERDOSAGE
Clinical Presentation
Acute overdose with Nalbuphine Hydrochloride Injection alone can be manifested by respiratory...
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Description
DESCRIPTION
Nalbuphine hydrochloride is a synthetic opioid agonist-antagonist analgesic of the phenanthrene series. It is chemically related to both the widely used opioid antagonist, naloxone, and the potent opioid...
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Clinical Pharmacology
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CLINICAL PHARMACOLOGY
Mechanism of Action
Nalbuphine is an agonist at kappa opioid receptors and an antagonist at mµ opioid receptors.
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How Supplied/Storage and Handling
HOW SUPPLIED
Nalbuphine Hydrochloride Injection is supplied as a sterile solution in single-dose ampuls and multiple‑dose fliptop vials for intramuscular, subcutaneous, or intravenous administration, and available as follows...
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