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nalbuphine hydrochloride injection

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nalbuphine hydrochloride injection Quick Finder

WARNING: SERIOUS AND LIFE-THREATENING RISKS FROM USE OF NALBUPHINE HYDROCHLORIDE INJECTION

Life-Threatening Respiratory Depression

Serious, life-threatening, or fatal...

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INDICATIONS AND USAGE

Nalbuphine Hydrochloride Injection is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Nalbuphine Hydrochloride...

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DOSAGE AND ADMINISTRATION

Important Dosage and Administration Instructions

Nalbuphine Hydrochloride Injection should be administered as a supplement to general...

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CONTRAINDICATIONS

Nalbuphine Hydrochloride Injection is contraindicated in patients with:

Significant respiratory depression [see WARNINGS]
•...
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WARNINGS

Life-Threatening Respiratory Depression

Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used...

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ADVERSE REACTIONS

The following serious adverse reactions are described, or described in greater detail, in other sections:‎

Opioid-Induced Hyperalgesia and Allodynia [see ...
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DRUG ABUSE AND DEPENDENCE

Abuse

Nalbuphine Hydrochloride Injection contains nalbuphine, a substance which is subject to misuse and abuse, which can lead to the ‎...

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OVERDOSAGE

Clinical Presentation

Acute overdose with Nalbuphine Hydrochloride Injection alone can be manifested by respiratory...

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DESCRIPTION

Nalbuphine hydrochloride is a synthetic opioid agonist-antagonist analgesic of the phenanthrene series. It is chemically related to both the widely used opioid antagonist, naloxone, and the potent opioid...

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CLINICAL PHARMACOLOGY

Mechanism of Action

Nalbuphine is an agonist at kappa opioid receptors and an antagonist at mµ opioid receptors.

...
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HOW SUPPLIED

Nalbuphine Hydrochloride Injection is supplied as a sterile solution in single-dose ampuls and multiple‑dose fliptop vials for intramuscular, subcutaneous, or intravenous administration, and available as follows...

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Injection
Ampul
Fliptop Vial
Protect from light.

...
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