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LYRICA®, CV (pregabalin)

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LYRICA®, CV Quick Finder

HIGHLIGHTS OF PRESCRIBING INFORMATION

These highlights do not include all the...
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1 INDICATIONS AND USAGE

LYRICA is indicated for:

  • Management of neuropathic pain associated with diabetic peripheral neuropathy
  • Management of...
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2 DOSAGE AND ADMINISTRATION

2.1 Important Administration Instructions

LYRICA is given orally with or without food.

When discontinuing LYRICA, taper gradually...

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3 DOSAGE FORMS AND STRENGTHS

Capsules: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, and 300 mg

Oral Solution: 20 mg/mL

[see Description (11) and How...

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4 CONTRAINDICATIONS

LYRICA is contraindicated in patients with known hypersensitivity to pregabalin or any of its components. Angioedema and hypersensitivity reactions have occurred in patients receiving pregabalin therapy...

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5 WARNINGS AND PRECAUTIONS

5.1 Angioedema

There have been postmarketing reports of angioedema in patients during initial and chronic treatment with LYRICA. Specific...

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6 ADVERSE REACTIONS

The following serious adverse reactions are described elsewhere in the labeling:

  • Angioedema [see

    6.1 Clinical Trials Experience

    ...

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7 DRUG INTERACTIONS

Since LYRICA is predominantly excreted unchanged in the urine, undergoes negligible metabolism in humans (less than 2% of a dose recovered in urine as metabolites), and does not bind to plasma proteins,...

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8 USE IN SPECIFIC POPULATIONS

8.1 Pregnancy

Pregnancy Exposure Registry

There is...

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9 DRUG ABUSE AND DEPENDENCE

9.1 Controlled Substance

LYRICA is a Schedule V controlled substance.

LYRICA is not known to be active at receptor sites associated...

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10 OVERDOSAGE

Signs, Symptoms and Laboratory Findings of Acute Overdosage in Humans

In the postmarketing experience, the most commonly...

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11 DESCRIPTION

Pregabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C8H17NO...

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12 CLINICAL PHARMACOLOGY

12.1 Mechanism of Action

LYRICA (pregabalin) binds with high affinity to the alpha2-delta site (an auxiliary subunit...

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13 NONCLINICAL TOXICOLOGY

13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility

...

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14 CLINICAL STUDIES

14.1 Neuropathic Pain Associated with Diabetic Peripheral Neuropathy

The efficacy of the maximum recommended dose of LYRICA for the management of...

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16 HOW SUPPLIED/STORAGE AND HANDLING

25 mg capsules:

White, hard-gelatin capsule printed with black ink "Pfizer" on the cap, "PGN 25" on the...

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MEDICATION GUIDE
LYRICA (LEER-i-kah)
(pregabalin)
Capsules, CV
...
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This product's labeling may have been updated. For the most recent prescribing information, please visit www.pfizer.com.

...

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Resources

LYRICA / LYRICA CR Co-Pay Card
For questions regarding the LYRICA / LYRICA CR Co-Pay Card, please call (800) 578-7076.
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