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linezolid injection in sodium chloride
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linezolid injection in sodium chloride Quick Finder
Highlights
Indications and Usage
1 INDICATIONS AND USAGE
1.1 Nosocomial Pneumonia
Linezolid is indicated for the treatment of nosocomial pneumonia caused by Staphylococcus...
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Dosage and Administration
2 DOSAGE AND ADMINISTRATION
2.1 General Dosage and Administration
The recommended dosage for linezolid injection for the treatment of infections is described in...
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Dosage Forms and Strengths
3 DOSAGE FORMS AND STRENGTHS
Linezolid injection: 600 mg/300 mL (2 mg/mL) linezolid in single-dose, ready-to-use flexible plastic container in a foil laminate overwrap.
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Contraindications
4 CONTRAINDICATIONS
4.1 Hypersensitivity
Linezolid injection is contraindicated for use in patients who have known hypersensitivity to linezolid or any of the other...
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Warnings and Precautions
5 WARNINGS AND PRECAUTIONS
5.1 Myelosuppression
Myelosuppression (including anemia, leukopenia, pancytopenia,...
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Adverse Reactions
6 ADVERSE REACTIONS
6.1 Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction...
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Drug Interactions
7 DRUG INTERACTIONS
7.1 Monoamine Oxidase Inhibitors
Linezolid is a reversible, nonselective inhibitor of monoamine oxidase [...
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Use in Specific Populations
8 USE IN SPECIFIC POPULATIONS
8.1 Pregnancy
...
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Overdosage
10 OVERDOSAGE
In the event of overdosage, supportive care is advised, with maintenance of glomerular filtration. Hemodialysis may facilitate more rapid elimination of linezolid. In a Phase 1 clinical trial, approximately 30...
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Description
11 DESCRIPTION
Linezolid injection contains linezolid, which is a synthetic antibacterial agent of the oxazolidinone class. The chemical name for linezolid is (S)-N...
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Clinical Pharmacology
12 CLINICAL PHARMACOLOGY
12.1 Mechanism of Action
Linezolid is an antibacterial drug [see Microbiology (...
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Nonclinical Toxicology
13 NONCLINICAL TOXICOLOGY
13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility
Lifetime studies in animals have not been conducted to...
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Clinical Studies
14 CLINICAL STUDIES
14.1 Adults
Nosocomial Pneumonia
...
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How Supplied/Storage and Handling
16 HOW SUPPLIED/STORAGE AND HANDLING
Linezolid injection is available in a single-dose, ready-to-use flexible plastic container in a foil laminate overwrap. The container is available in the following package size:
...
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Medication Guide
17 PATIENT COUNSELING INFORMATION
Important Administration Instructions
Advise patients that linezolid injection...
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