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GLUCOTROL®(glipizide)

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GLUCOTROL® Quick Finder

INDICATIONS AND USAGE

GLUCOTROL is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

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DOSAGE AND ADMINISTRATION

There is no fixed dosage regimen for the management of diabetes mellitus with GLUCOTROL or any other hypoglycemic agent. In addition to the usual monitoring of urinary glucose, the patient's blood...

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CONTRAINDICATIONS

GLUCOTROL is contraindicated in patients with:

  1. Known hypersensitivity to the drug.
  2. Type 1 diabetes mellitus, diabetic ketoacidosis, with or without coma. This condition should be treated...
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WARNINGS

SPECIAL WARNING ON INCREASED RISK OF CARDIOVASCULAR MORTALITY

The administration of oral hypoglycemic drugs has been reported to be...

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ADVERSE REACTIONS

In U.S. and foreign controlled studies, the frequency of serious adverse reactions reported was very low. Of 702 patients, 11.8% reported adverse reactions and in only 1.5% was GLUCOTROL discontinued.

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OVERDOSAGE

There is no well documented experience with GLUCOTROL overdosage. The acute oral toxicity was extremely low in all species tested (LD50 greater than 4 g/kg).

Overdosage of...

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DESCRIPTION

GLUCOTROL (glipizide) is an oral blood-glucose-lowering drug of the sulfonylurea class.

The Chemical Abstracts name of glipizide is 1-cyclohexyl-3-[[p-[2-(5-methylpyrazine-carboxamido)ethyl]phenyl]sulfonyl]...

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CLINICAL PHARMACOLOGY

Mechanism of Action

The primary mode of action of GLUCOTROL in experimental animals appears to be the stimulation of insulin secretion from the...

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HOW SUPPLIED

GLUCOTROL tablets are white, dye-free, scored, diamond-shaped, and imprinted as follows:

5 mg–Pfizer 411; 10 mg–Pfizer 412.

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