WARNINGS: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER AND PROBABLE DEMENTIA
Estrogen-Alone Therapy
Endometrial...
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ESTRING®(estradiol)
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ESTRING® Quick Finder
Indications and Usage
INDICATIONS AND USAGE
ESTRING is indicated for the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.
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Dosage and Administration
DOSAGE AND ADMINISTRATION
One ESTRING (estradiol vaginal ring) is to be inserted as deeply as possible into the upper one-third of the vaginal vault. The ring is to remain in place continuously for three months, after which...
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Contraindications
CONTRAINDICATIONS
ESTRING is contraindicated in women with any of the following conditions:
- Undiagnosed abnormal genital bleeding.
- Known, suspected, or history of breast cancer.
- Known or suspected...
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Warnings and Precautions
WARNINGS
See BOXED WARNINGS
ESTRING is a vaginal administered product with low systemic absorption following continuous use for 3 months (see CLINICAL...
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Adverse Reactions
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Overdosage
OVERDOSAGE
Overdosage of estrogen may cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding may occur in women. Treatment of overdose consists of discontinuation of ESTRING...
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Description
DESCRIPTION
ESTRING® (estradiol vaginal ring) is a slightly opaque ring with a whitish core containing a drug reservoir of 2 mg estradiol. Estradiol, silicone polymers and barium sulfate are combined to form the ring. When...
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Clinical Pharmacology
CLINICAL PHARMACOLOGY
Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic...
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Clinical Studies
CLINICAL STUDIES
Effects on vulvar and vaginal atrophy
Two controlled studies have demonstrated the efficacy of ESTRING (estradiol vaginal ring) in the treatment of...
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How Supplied/Storage and Handling
HOW SUPPLIED
Each ESTRING (estradiol vaginal ring) is individually packaged in a heat-sealed rectangular pouch consisting of three layers, from outside to inside: polyester, aluminum foil, and low density polyethylene,...
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Medication Guide
PATIENT INFORMATION
ESTRING
(estradiol vaginal ring)
Read this Patient Information before you start using ESTRING and each time you get a refill. There may be new information. This...
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FDA-Approved Patient Labeling
PATIENT INFORMATION
ESTRING
(estradiol vaginal ring)
Read this Patient Information before you start using ESTRING and each time you get a refill. There may be new information. This...
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Instructions For Use
INSTRUCTIONS FOR USE
How should I use ESTRING?
ESTRING is a local estrogen therapy used after menopause to treat moderate to severe menopausal changes in and around the vagina. ESTRING...
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