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ESTRING®(estradiol)

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ESTRING® Quick Finder

WARNINGS: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER AND PROBABLE DEMENTIA

Estrogen-Alone Therapy

Endometrial...

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INDICATIONS AND USAGE

ESTRING is indicated for the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.

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DOSAGE AND ADMINISTRATION

One ESTRING (estradiol vaginal ring) is to be inserted as deeply as possible into the upper one-third of the vaginal vault. The ring is to remain in place continuously for three months, after which...

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CONTRAINDICATIONS

ESTRING is contraindicated in women with any of the following conditions:

  1. Undiagnosed abnormal genital bleeding.
  2. Known, suspected, or history of breast cancer.
  3. Known or suspected...
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WARNINGS

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1. Cardiovascular Disorders

An increased risk of stroke and DVT has been reported with estrogen-alone therapy. An increased risk of stroke, DVT, PE, and MI has been...

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ADVERSE REACTIONS

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Table 4: Adverse Events Reported by 3 Percent or More of Patients Receiving Either ESTRING or Conjugated Estrogens Vaginal Cream in Two Pivotal...

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OVERDOSAGE

Overdosage of estrogen may cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding may occur in women. Treatment of overdose consists of discontinuation of ESTRING...

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DESCRIPTION

ESTRING® (estradiol vaginal ring) is a slightly opaque ring with a whitish core containing a drug reservoir of 2 mg estradiol. Estradiol, silicone polymers and barium sulfate are combined to form the ring. When...

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CLINICAL PHARMACOLOGY

Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic...

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CLINICAL STUDIES

Effects on vulvar and vaginal atrophy

Two controlled studies have demonstrated the efficacy of ESTRING (estradiol vaginal ring) in the treatment of...

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HOW SUPPLIED

Each ESTRING (estradiol vaginal ring) is individually packaged in a heat-sealed rectangular pouch consisting of three layers, from outside to inside: polyester, aluminum foil, and low density polyethylene,...

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PATIENT INFORMATION

ESTRING
(estradiol vaginal ring)

Read this Patient Information before you start using ESTRING and each time you get a refill. There may be new information. This...

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INSTRUCTIONS FOR USE

How should I use ESTRING?

ESTRING is a local estrogen therapy used after menopause to treat moderate to severe menopausal changes in and around the vagina. ESTRING...

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PHYSICIAN'S LEAFLET

Rx only

...

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Resources

ESTRING Co-Pay Card
For questions regarding the ESTRING Co-Pay Card, please call (800) 631-1181
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