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CALAN®(verapamil hydrochloride tablets)

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CALAN® Quick Finder

INDICATIONS AND USAGE

CALAN tablets are indicated for the treatment of the following:

Angina

  1. Angina at rest including:
    ...
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DOSAGE AND ADMINISTRATION

The dose of verapamil must be individualized by titration. The usefulness and safety of dosages exceeding 480 mg/day have not been established; therefore, this daily dosage should not be exceeded....

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CONTRAINDICATIONS

Verapamil HCl tablets are contraindicated in:

  1. Severe left ventricular dysfunction (see WARNINGS)
  2. Hypotension (systolic pressure less than...
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WARNINGS

Heart failure

Verapamil has a negative inotropic effect, which in most patients is compensated by its afterload reduction (decreased systemic vascular...

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ADVERSE REACTIONS

Serious adverse reactions are uncommon when CALAN therapy is initiated with upward dose titration within the recommended single and total daily dose. See

Treatment of acute...

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OVERDOSAGE

Treat all verapamil overdoses as serious and maintain observation for at least 48 hours (especially CALAN SR), preferably under continuous hospital care. Delayed pharmacodynamic consequences may occur with the...

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DESCRIPTION

CALAN (verapamil HCl) is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) available for oral administration in film-coated tablets containing 80 mg or 120 mg of verapamil...

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CLINICAL PHARMACOLOGY

CALAN is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell membrane of the...

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Animal pharmacology and/or animal toxicology

In chronic animal toxicology studies, verapamil caused lenticular and/or suture line changes at 30 mg/kg/day or greater, and frank cataracts at 62.5 mg/kg/day or greater in the...

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HOW SUPPLIED

CALAN 80 mg tablets are oval, peach colored, scored, film coated, with CALAN debossed on one side and 80 on the other, supplied as:

...
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LAB-0269-14.0
September 2017

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