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ACCURETIC®(quinapril HCl, hydrochlorothiazide)

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ACCURETIC® Quick Finder

WARNING: FETAL TOXICITY

  • When pregnancy is detected, discontinue ACCURETIC as soon as possible.
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing...
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INDICATIONS AND USAGE

Hypertension

ACCURETIC is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal...

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DOSAGE AND ADMINISTRATION

As individual monotherapy, quinapril is an effective treatment of hypertension in once-daily doses of 10 to 80 mg and hydrochlorothiazide is effective in doses of 12.5 to 50 mg. In clinical trials...

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CONTRAINDICATIONS

ACCURETIC is contraindicated in patients who are hypersensitive to quinapril or hydrochlorothiazide and in patients with a history of angioedema related to previous treatment with an ACE inhibitor.

...

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WARNINGS

Anaphylactoid and Possibly Related Reactions

Presumably because angiotensin converting inhibitors affect the metabolism of eicosanoids and polypeptides,...

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ADVERSE REACTIONS

ACCURETIC has been evaluated for safety in 1571 patients in controlled and uncontrolled studies. Of these, 498 were given quinapril plus hydrochlorothiazide for at least 1 year, with 153 patients extending...

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OVERDOSAGE

No specific information is available on the treatment of overdosage with ACCURETIC or quinapril monotherapy; treatment should be symptomatic and supportive. Therapy with ACCURETIC should be discontinued, and the...

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DESCRIPTION

ACCURETIC is a fixed-combination tablet that combines an angiotensin-converting enzyme (ACE) inhibitor, quinapril hydrochloride, and a thiazide diuretic, hydrochlorothiazide.

Quinapril hydrochloride is...

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CLINICAL PHARMACOLOGY

Mechanism of Action

The principal metabolite of quinapril, quinaprilat, is an inhibitor of ACE activity in human subjects and animals. ACE is...

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HOW SUPPLIED

ACCURETIC is available in tablets of three different strengths:

10/12.5 tablets: pink, scored elliptical, biconvex, film-coated tablets coded "PD 222" on one side. Each tablet...

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LAB-0216-22.0
Revised: February 2021

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