WARNING: FETAL TOXICITY
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- When pregnancy is detected, discontinue ACCUPRIL as soon as possible.
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- Drugs that act directly on the renin-angiotensin system can...
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ACCUPRIL®(quinapril HCl)
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ACCUPRIL® Quick Finder
Boxed Warning
Indications and Usage
INDICATIONS AND USAGE
Hypertension
ACCUPRIL is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal...
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Dosage and Administration
DOSAGE AND ADMINISTRATION
Hypertension
Monotherapy
The recommended initial dosage...
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Contraindications
CONTRAINDICATIONS
ACCUPRIL is contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an ACE inhibitor.
ACCUPRIL is...
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Warnings and Precautions
WARNINGS
Anaphylactoid and Possibly Related Reactions
Presumably because ACE inhibitors affect the metabolism of eicosanoids and polypeptides, including endogenous...
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Adverse Reactions
ADVERSE REACTIONS
Hypertension
ACCUPRIL has been evaluated for safety in 4960 subjects and patients. Of these, 3203 patients, including 655 elderly patients,...
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Overdosage
OVERDOSAGE
Doses of 1440 to 4280 mg/kg of quinapril cause significant lethality in mice and rats.
No specific information is available on the treatment of overdosage with quinapril. The most likely clinical...
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Description
DESCRIPTION
ACCUPRIL® is the hydrochloride salt of quinapril, the ethyl ester of a non-sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat.
Quinapril hydrochloride is...
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Clinical Pharmacology
CLINICAL PHARMACOLOGY
Mechanism of Action
Quinapril is deesterified to the principal metabolite, quinaprilat, which is an inhibitor of ACE activity in human subjects...
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How Supplied/Storage and Handling
HOW SUPPLIED
ACCUPRIL tablets are supplied as follows:
5-mg tablets: brown, film-coated, elliptical scored tablets, coded "PD 527"on one side and "5"on the other.
NDC 0071-0527-23 bottles...
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