ACCUPRIL® (quinapril HCl) Patient information | Pfizer Medical Information - US

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ACCUPRIL® Quick Finder

Availability

Pfizer is experiencing a supply shortage of Accupril because of manufacturing disruptions. While Pfizer is managing this situation with urgency, at this time, we are unable to confirm a date when the situation will be resolved.

We understand and regret the challenges that this situation poses to patients. Pfizer fully realizes the importance of this medicine to patients. Ensuring continuity of the supply of our medicines is paramount. Until the Accupril shortage is resolved, patients will need to consult with their healthcare professional to choose an alternate treatment option.

Please refer to the full Prescribing Information on important treatment considerations for Accupril via the following link. In the event this link does not work, please access the product’s approved Prescribing Information at www.pfizer.com/products.
Need Information on Pfizer’s Patient Assistance Programs?

Pfizer RxPathways connects eligible patients to a range of assistance programs that offer insurance support, co-pay help, and medicines for free or at a savings. Patients and physicians can contact RxPathways at (866) 706-2400 or visit the website for more information on these programs www.pfizerrxpathways.com.
Have a Question about Pfizer Clinical Trials?

If you are looking for information about Pfizer studies currently recruiting new patients in your area, you can begin your search on our website. For questions about a Pfizer Clinical Trial, call (800) 718-1021 or email [email protected]
Need to report an Adverse Event, Side Effect, or Product Quality Concern?

Contact Pfizer Safety to report an adverse event, side effect or concern about the quality of a Pfizer product: (800) 438-1985

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns at 1-800-FDA-1088 or www.fda.gov/MedWatch
Resources

Download Prescribing Information

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WARNING: FETAL TOXICITY

•: When pregnancy is detected, discontinue ACCUPRIL as soon as possible.
•: Drugs that act directly on the renin-angiotensin system can...

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INDICATIONS AND USAGE

Hypertension

ACCUPRIL is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal...

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DOSAGE AND ADMINISTRATION

Hypertension

Monotherapy:

The recommended initial dosage of ACCUPRIL in patients...

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CONTRAINDICATIONS

ACCUPRIL is contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an ACE inhibitor.

ACCUPRIL is...

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WARNINGS

Anaphylactoid and Possibly Related Reactions

Presumably because ACE inhibitors affect the metabolism of eicosanoids and polypeptides, including endogenous...

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ADVERSE REACTIONS

Hypertension

ACCUPRIL has been evaluated for safety in 4960 subjects and patients. Of these, 3203 patients, including 655 elderly patients,...

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OVERDOSAGE

Doses of 1440 to 4280 mg/kg of quinapril cause significant lethality in mice and rats.

No specific information is available on the treatment of overdosage with quinapril. The most likely clinical...

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DESCRIPTION

ACCUPRIL® is the hydrochloride salt of quinapril, the ethyl ester of a non-sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat.

Quinapril hydrochloride is...

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CLINICAL PHARMACOLOGY

Mechanism of Action:

Quinapril is deesterified to the principal metabolite, quinaprilat, which is an inhibitor of ACE activity in human subjects...

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HOW SUPPLIED

ACCUPRIL tablets are supplied as follows:

5-mg tablets: brown, film-coated, elliptical scored tablets, coded "PD 527"on one side and "5"on the other.
NDC 0071-0527-23 bottles...

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LAB-0215-20.0

Revised September 2023

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Call (800) 438-1985

Contact Pfizer Medical Information to speak with a professional regarding your medical question on a Pfizer prescription product: (800) 438-1985

Report Adverse Event

Pfizer Safety

To report an adverse event related to a Pfizer product and you are not part of a clinical trial* for this product, click the link below to submit your information: Pfizer Safety Reporting Site

*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.

If you cannot use the above website to report an adverse event related to a Pfizer product, please call Pfizer Medical Information at (800) 438-1985.

FDA Medwatch

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatchor by calling
(800)-332-1088.