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ACCUPRIL®(quinapril HCl)

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ACCUPRIL® Quick Finder

WARNING: FETAL TOXICITY

  • When pregnancy is detected, discontinue ACCUPRIL as soon as possible.
  • Drugs that act directly on the renin-angiotensin system can cause injury and death...
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INDICATIONS AND USAGE

Hypertension

ACCUPRIL is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal...

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DOSAGE AND ADMINISTRATION

Hypertension

Monotherapy

The recommended initial dosage of ACCUPRIL in patients not...

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CONTRAINDICATIONS

ACCUPRIL is contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an ACE inhibitor.

ACCUPRIL is...

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WARNINGS

Anaphylactoid and Possibly Related Reactions

Presumably because ACE inhibitors affect the metabolism of eicosanoids and polypeptides, including endogenous...

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ADVERSE REACTIONS

Hypertension

ACCUPRIL has been evaluated for safety in 4960 subjects and patients. Of these, 3203 patients, including 655 elderly patients,...

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OVERDOSAGE

Doses of 1440 to 4280 mg/kg of quinapril cause significant lethality in mice and rats.

No specific information is available on the treatment of overdosage with quinapril. The most likely clinical...

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DESCRIPTION

ACCUPRIL® is the hydrochloride salt of quinapril, the ethyl ester of a non-sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat.

Quinapril hydrochloride is...

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CLINICAL PHARMACOLOGY

Mechanism of Action

Quinapril is deesterified to the principal metabolite, quinaprilat, which is an inhibitor of ACE activity in human subjects...

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HOW SUPPLIED

ACCUPRIL tablets are supplied as follows:

5-mg tablets: brown, film-coated, elliptical scored tablets, coded "PD 527"on one side and "5"on the other.
NDC 0071-0527-23 bottles...

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LAB-0215-18.0

Revised August 2021

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