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pamidronate disodium injection

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pamidronate disodium injection Quick Finder

INDICATIONS AND USAGE

Hypercalcemia of Malignancy 

Pamidronate disodium, in conjunction with adequate hydration, is indicated for the treatment of moderate or...

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DOSAGE AND ADMINISTRATION

Hypercalcemia of Malignancy

Consideration should be given to the severity of as well as the symptoms of hypercalcemia. Vigorous saline...

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CONTRAINDICATIONS

Pamidronate disodium is contraindicated in patients with clinically significant hypersensitivity to pamidronate disodium or other bisphosphonates.

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WARNINGS

Deterioration in Renal Function

Bisphosphonates, including pamidronate disodium, have been associated with renal toxicity manifested as deterioration of...

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ADVERSE REACTIONS

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another...

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OVERDOSAGE

There have been several cases of drug maladministration of intravenous pamidronate disodium in hypercalcemia patients with total doses of 225 mg to 300 mg given over 2½ to 4 days. All of these patients survived,...

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DESCRIPTION

Pamidronate disodium is a bisphosphonate available in 30 mg, 60 mg, or 90 mg vials for intravenous administration. The pamidronate disodium obtained by combining pamidronic acid and sodium hydroxide is provided...

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CLINICAL PHARMACOLOGY

The principal pharmacologic action of pamidronate disodium is inhibition of bone resorption. Although the mechanism of antiresorptive action is not completely understood, several factors are thought to...

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HOW SUPPLIED

Vials – 3 mg/mL, 10 mL vial - each contains 30 mg of Pamidronate Disodium and 470 mg of Mannitol, USP in 10 mL Water for Injection, USP.

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For Intravenous Infusion

Rx only 

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