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pamidronate disodium injection

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Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

pamidronate disodium injection Quick Finder

INDICATIONS AND USAGE

Hypercalcemia of Malignancy 

Pamidronate disodium, in conjunction with adequate hydration, is indicated for the treatment of moderate or...

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DOSAGE AND ADMINISTRATION

Hypercalcemia of Malignancy

Consideration should be given to the severity of as well as the symptoms of hypercalcemia. Vigorous saline...

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CONTRAINDICATIONS

Pamidronate disodium is contraindicated in patients with clinically significant hypersensitivity to pamidronate disodium or other bisphosphonates.

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WARNINGS

Deterioration in Renal Function

Bisphosphonates, including pamidronate disodium, have been associated with renal toxicity manifested as deterioration of...

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ADVERSE REACTIONS

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another...

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OVERDOSAGE

There have been several cases of drug maladministration of intravenous pamidronate disodium in hypercalcemia patients with total doses of 225 mg to 300 mg given over 2½ to 4 days. All of these patients survived,...

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DESCRIPTION

Pamidronate disodium is a bisphosphonate available in 30 mg, 60 mg, or 90 mg vials for intravenous administration. The pamidronate disodium obtained by combining pamidronic acid and sodium hydroxide is provided...

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CLINICAL PHARMACOLOGY

The principal pharmacologic action of pamidronate disodium is inhibition of bone resorption. Although the mechanism of antiresorptive action is not completely understood, several factors are thought to...

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HOW SUPPLIED

Vials – 3 mg/mL, 10 mL vial - each contains 30 mg of Pamidronate Disodium and 470 mg of Mannitol, USP in 10 mL Water for Injection, USP.

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For Intravenous Infusion

Rx only 

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