2 DOSAGE AND ADMINISTRATION
2.1 Recommended Dosage
Prevention of Chemotherapy-Induced Nausea and Vomiting
The recommended dosage of Palonosetron HCl Injection for prevention of nausea and vomiting associated with HEC and MEC in adults and associated with emetogenic chemotherapy, including HEC in pediatric patients 1 month to less than 17 years of age is shown in Table 1.
|Adults||0.25 mg as a single dose||Infuse over 30 seconds beginning approximately 30 minutes before the start of chemotherapy|
|Pediatrics (1 month to less than 17 years)||20 micrograms per kilogram (max 1.5 mg as a single dose)||Infuse over 15 minutes beginning approximately 30 minutes before the start of chemotherapy|
2.2 Instructions for Intravenous Administration
- Palonosetron HCl Injection is supplied ready for intravenous administration at a concentration of 0.05 mg/mL (50 mcg/mL).
- Do not mix Palonosetron HCl Injection with other drugs.
- Flush the infusion line with normal saline before and after administration of Palonosetron HCl Injection.
- Inspect Palonosetron HCl Injection visually for particulate matter and discoloration before administration.
- Discard unused portion.