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dopamine Hydrochloride in 5% dextrose injection, USP Drug Interactions


See Table 1 for clinically significant drug interactions with dopamine.

Table 1: Clinically Significant Drug Interactions with Dopamine
Halogenated Anesthetics
Clinical Impact:Concomitant use may increase cardiac autonomic irritability and can sensitize the myocardium to the action of dopamine which may lead to ventricular arrhythmias and hypertension.
Intervention:Monitor cardiac rhythm.
Examples:desflurane, enflurane, isoflurane, and sevoflurane.
MAO Inhibitors
Clinical Impact:Because dopamine is metabolized by monoamine oxidase (MAO), inhibition of this enzyme prolongs and potentiates the effect of dopamine which may result in severe hypertension and cardiac arrhythmia.
Intervention:Reduce the recommended starting dosage to no greater than one-tenth (1/10) of the recommended dose in patients who have been treated with MAO inhibitors within two to three weeks prior to the administration of Dopamine HCl in Dextrose Injection.
Examples:isocarboxazid, phenelzine, tranylcypromine, rasagiline, selegiline, linezolid.
Tricyclic Antidepressants
Clinical Impact:Concomitant use may potentiate the cardiovascular effects of dopamine (e.g., hypertension).
Intervention:Monitor blood pressure.
Examples:amitriptyline, desipramine, doxepin, imipramine, nortriptyline.
Clinical Impact:Concomitant use may result in severe hypertension.
Intervention:Monitor blood pressure.
Examples:norepinephrine, epinephrine, oxytocin.
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