6 ADVERSE REACTIONS
The following adverse reactions are discussed in more detail elsewhere in the label:
- Hypotension [see Warnings and Precautions (5.2)]
- Headache [see Warnings and Precautions (5.4)]
- Hypersensitivity [see Contraindications (4.4)]
Vertigo, dizziness, weakness, palpitation, and other manifestations of postural hypotension may develop occasionally, particularly in erect, immobile patients. Marked sensitivity to the hypotensive effects of nitrates (manifested by nausea, vomiting, weakness, diaphoresis, pallor, and collapse) may occur at therapeutic doses. Syncope due to nitrate vasodilatation has been reported.
Flushing, drug rash, and exfoliative dermatitis have been reported in patients receiving nitrate therapy.