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Naloxone hydrochloride injection is indicated for the complete or partial reversal of opioid depression, including respiratory depression, induced by natural and synthetic opioids including propoxyphene...
Naloxone hydrochloride injection may be administered intravenously, intramuscularly, or subcutaneously. The most rapid onset of action is achieved by intravenous administration and it is recommended...
Naloxone hydrochloride injection is contraindicated in patients known to be hypersensitive to naloxone hydrochloride or any of the other ingredients contained in the formulation.
Drug Dependence
Naloxone hydrochloride injection should be administered cautiously to persons including newborns of mothers who are known or suspected to...
Postoperative
The following adverse events have been associated with the use of naloxone hydrochloride injection in postoperative patients:...
Naloxone hydrochloride injection is an opioid antagonist. Physical dependence associated with the use of naloxone hydrochloride injection has not been reported. Tolerance to the opioid antagonist...
There is limited clinical experience with naloxone hydrochloride injection overdosage in humans.
Adult Patients
In one small study, volunteers...
Naloxone hydrochloride, an opioid antagonist, is a synthetic congener of oxymorphone. In structure it differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group. It is...
Naloxone prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists...
Naloxone hydrochloride injection, USP for intravenous, intramuscular, and subcutaneous administration is available as:
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