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naloxone hydrochloride injection, USP - CARPUJECT

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Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

naloxone hydrochloride injection, USP - CARPUJECT Quick Finder

INDICATIONS AND USAGE

Naloxone hydrochloride injection is indicated for the complete or partial reversal of opioid depression, including respiratory depression, induced by natural and synthetic opioids including propoxyphene...

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DOSAGE AND ADMINISTRATION

Naloxone hydrochloride injection may be administered intravenously, intramuscularly, or subcutaneously. The most rapid onset of action is achieved by intravenous administration and it is recommended...

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CONTRAINDICATIONS

Naloxone hydrochloride injection is contraindicated in patients known to be hypersensitive to naloxone hydrochloride or any of the other ingredients contained in the formulation.

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WARNINGS

Drug Dependence

Naloxone hydrochloride injection should be administered cautiously to persons including newborns of mothers who are known or suspected to...

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ADVERSE REACTIONS

Postoperative

The following adverse events have been associated with the use of naloxone hydrochloride injection in postoperative patients:...

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DRUG ABUSE AND DEPENDENCE

Naloxone hydrochloride injection is an opioid antagonist. Physical dependence associated with the use of naloxone hydrochloride injection has not been reported. Tolerance to the opioid antagonist...

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OVERDOSAGE

There is limited clinical experience with naloxone hydrochloride injection overdosage in humans.

Adult Patients

In one small study, volunteers...

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DESCRIPTION

Naloxone hydrochloride, an opioid antagonist, is a synthetic congener of oxymorphone. In structure it differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group. It is...

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CLINICAL PHARMACOLOGY

Naloxone prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists...

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HOW SUPPLIED

Naloxone hydrochloride injection, USP for intravenous, intramuscular, and subcutaneous administration is available as:

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Opioid Antagonist

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