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nalbuphine hydrochloride injection

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Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

nalbuphine hydrochloride injection Quick Finder

WARNING: LIFE-THREATENING RESPIRATORY DEPRESSION and RISKS FROM CONCOMITANT USE WITH BENZODIAZEPINES OR OTHER CNS DEPRESSANTS

Life-Threatening Respiratory Depression

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INDICATIONS AND USAGE

Nalbuphine Hydrochloride Injection is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Nalbuphine Hydrochloride...

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DOSAGE AND ADMINISTRATION

Important Dosage and Administration Instructions

Nalbuphine Hydrochloride Injection should be administered as a...

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CONTRAINDICATIONS

Nalbuphine Hydrochloride Injection is contraindicated in patients with:

  • Significant respiratory depression [see WARNINGS]
  • ...
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WARNINGS

Life-Threatening Respiratory Depression

Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used...

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ADVERSE REACTIONS

The most frequent adverse reaction in 1066 patients treated in clinical studies with Nalbuphine Hydrochloride Injection was sedation 381 (36%).

Less frequent reactions were: sweaty/clammy 99 (9%),...

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DRUG ABUSE AND DEPENDENCE

Abuse

Nalbuphine Hydrochloride Injection contains nalbuphine, which can be abused and is subject to misuse, addiction, and criminal diversion...

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OVERDOSAGE

Clinical Presentation

Acute overdose with Nalbuphine Hydrochloride Injection alone can be manifested by respiratory depression and dysphoria. Acute overdose...

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DESCRIPTION

Nalbuphine hydrochloride is a synthetic opioid agonist-antagonist analgesic of the phenanthrene series. It is chemically related to both the widely used opioid antagonist, naloxone, and the potent opioid analgesic...

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CLINICAL PHARMACOLOGY

Mechanism of Action

Nalbuphine is an agonist at kappa opioid receptors and an antagonist at mµ opioid receptors.

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HOW SUPPLIED

Nalbuphine Hydrochloride Injection for intramuscular, subcutaneous, or intravenous use is a sterile solution available in:

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Injection
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Fliptop Vial
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