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morphine sulfate injection, USP ISECURE, CARPUJECT
If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents.
Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.
morphine sulfate injection, USP ISECURE, CARPUJECT Quick Finder
Highlights
Boxed Warning
WARNING: ADDICTION, ABUSE, AND MISUSE; LIFE-THREATENING RESPIRATORY DEPRESSION; NEONATAL OPIOID WITHDRAWAL SYNDROME; and RISKS FROM CONCOMITANT USE WITH BENZODIAZEPINES OR OTHER CNS DEPRESSANTS
...
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Indications and Usage
1 INDICATIONS AND USAGE
Morphine Sulfate Injection is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
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Dosage and Administration
2 DOSAGE AND ADMINISTRATION
2.1 Important Dosage and Administration Instructions
Morphine Sulfate Injection is for intravenous administration.
Morphine Sulfate...
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Dosage Forms and Strengths
3 DOSAGE FORMS AND STRENGTHS
Morphine Sulfate Injection, USP is a sterile, nonpyrogenic solution of morphine sulfate, free of antioxidants and preservatives to be administered by the intravenous route, available in the...
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Contraindications
4 CONTRAINDICATIONS
Morphine Sulfate Injection is contraindicated in patients with:
- •
- Significant respiratory depression [see Warnings and Precautions (5.2)]...
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Warnings and Precautions
5 WARNINGS AND PRECAUTIONS
5.1 Addiction, Abuse, and Misuse
Morphine Sulfate Injection contains morphine, a Schedule II controlled substance. As an opioid, Morphine...
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Drug Interactions
7 DRUG INTERACTIONS
Table 1 includes clinically significant drug interactions with Morphine Sulfate Injection.
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Use in Specific Populations
8 USE IN SPECIFIC POPULATIONS
8.1 Pregnancy
Risk Summary
Prolonged use of...
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Drug Abuse and Dependence
...
9 DRUG ABUSE AND DEPENDENCE
9.1 Controlled Substance
Morphine Sulfate Injection contains morphine, a Schedule II controlled substance.
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Overdosage
10 OVERDOSAGE
Clinical Presentation
Acute overdose with Morphine Sulfate Injection can be manifested by respiratory depression, somnolence...
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Description
11 DESCRIPTION
Morphine Sulfate Injection, USP is an opioid agonist, available in 2 mg/mL, 4 mg/mL, 8 mg/mL, 10 mg/mL, and 15 mg/mL (1 mL fill in 2.5 mL Carpuject™ Single‑dose cartridge with Luer Lock for the Carpuject™...
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Clinical Pharmacology
12 CLINICAL PHARMACOLOGY
12.1 Mechanism of Action
Morphine is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to...
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Nonclinical Toxicology
13 NONCLINICAL TOXICOLOGY
13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility
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How Supplied/Storage and Handling
16 HOW SUPPLIED/STORAGE AND HANDLING
Morphine Sulfate Injection, USP is supplied as a sterile solution in single-dose Carpuject™ cartridges for use ONLY with the Carpuject™ Holders and NexJect™ prefilled syringes for...
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Medication Guide
17 PATIENT COUNSELING INFORMATION
Serotonin Syndrome
Opioids can cause a rare but potentially life-threatening condition resulting from...
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Instructions For Use
INSTRUCTIONS FOR USE
Instructions for use - Carpuject™ Single-dose Cartridge
Parenteral drug products should be inspected visually for particulate matter and...
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Report Adverse Event
To report an adverse event related to a Pfizer product and you are not part of a clinical trial* for this product, click the link below to submit your information: Pfizer Safety Reporting Site
*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.
If you cannot use the above website to report an adverse event related to a Pfizer product, please call Pfizer Medical Information at (800) 438-1985.
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(800)-332-1088.