4 CONTRAINDICATIONS
Preservative-free morphine sulfate injection is contraindicated in patients with:
- Significant respiratory depression [see Warnings and Precautions (5.2)]
- Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment [see Warnings and Precautions (5.8)]
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or use of MAOIs within the last 14 days [see Warnings and Precautions (5.9)/Drug Interactions (7)]
- Known or suspected gastrointestinal obstruction, including paralytic ileus [see Warnings and Precautions (5.13)]
- Hypersensitivity to morphine (e.g., anaphylaxis) [See Adverse Reactions (6)]
Neuraxial administration of preservative-free morphine sulfate injection is contraindicated in patients with:
- Infection at the injection microinfusion site [see Warnings and Precautions (5.1)]
- Concomitant anticoagulant therapy [see Warnings and Precautions (5.1)]
- Uncontrolled bleeding diathesis [see Warnings and Precautions (5.1)]
- The presence of any other concomitant therapy or medical condition which would render epidural or intrathecal administration of medication especially hazardous.