16 HOW SUPPLIED/STORAGE AND HANDLING
How Supplied
Methotrexate Injection is a clear, yellow, sterile solution available with preservative (multiple-dose vials) and preservative-free (single-dose vials) as follows:
| Strength/Fill volume | NDC number | Pack style |
|---|---|---|
| With Preservative | ||
| 50 mg/2 mL (25 mg/mL) | 61703-350-38 | Carton containing five (5) multiple-dose vials |
| Preservative-free | ||
| 1 g/40 mL (25 mg/mL) | 61703-408-41 | Carton containing one (1) single-dose vial |
| Carton contents | NDC |
|---|---|
| Methotrexate Injection, With Preservative, 5 multiple-dose vials | |
| 50 mg/2 mL (25 mg/mL) | 61703-350-38 |
| Preservative-free Methotrexate Injection, 1 single-dose vial | |
| 1 g/40 mL (25 mg/mL) | 61703-408-41 |
Storage and Handling
Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Protect from light.
After first puncture, store multiple-dose vials at 2°C to 8°C, and use within 30 days.
Methotrexate Injection is a hazardous drug. Follow applicable special handling and disposal procedures.1