Medical Information
 

In order to provide you with relevant and meaningful content we need to know more about you.

Please choose the category that best describes you.

This content is intended for U.S. Healthcare Professionals. Would you like to proceed?

If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents.

Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.
Not a healthcare professional? Go to the patient or caregiver website.

MAGNESIUM SULFATE Highlights (magnesium sulfate injection, USP)

HIGHLIGHTS OF PRESCRIBING INFORMATION

These highlights do not include all the information needed to use MAGNESIUM SULFATE IN 5% DEXTROSE INJECTION safely and effectively. See full prescribing information for MAGNESIUM SULFATE IN 5% DEXTROSE INJECTION.

MAGNESIUM SULFATE IN DEXTROSE injection, for intravenous use
Initial U.S. Approval: 1941

INDICATIONS AND USAGE

Magnesium Sulfate in 5% Dextrose Injection is indicated for (1):

  • Prevention of eclampsia in patients with preeclampsia (1)
  • Treatment of seizures and prevention of recurrent seizures in patients with eclampsia (1)

DOSAGE AND ADMINISTRATION

  • Administer via intravenous infusion pump (2.1)
  • Recommended loading dosage is 4 to 6 grams over 15 minutes followed by a recommended maintenance dosage of 1 to 2 grams every hour; maximum recommended dosage is 30 to 40 grams over 24 hours (2.2)
  • Obtain serum magnesium concentrations and assess clinical status to adjust the dose (2.2)
  • Administration beyond 5 to 7 days is not recommended (2.2, 5.1)
  • In patients with severe renal impairment and/or urine output less than 0.5 mL/kg/hour, administer a 4 gram loading dose followed by a maintenance dosage of 1 gram every hour; do not exceed the maximum recommended dosage of 20 grams over 48 hours (2.3)
  • Do not administer Magnesium Sulfate in 5% Dextrose Injection with incompatible drugs through the same intravenous line, specifically with salicylates and alkali carbonates (2.4)

DOSAGE FORMS AND STRENGTHS

Supplied in premixed single-dose bags: (3)

  • 0.01 grams/mL (1%) in 100 mL bag containing 1 gram of magnesium sulfate in 5% dextrose injection

CONTRAINDICATIONS

  • Heart block or myocardial damage (4)
  • Diabetic coma (4)
  • Myasthenia gravis (4, 5.6)

WARNINGS AND PRECAUTIONS

  • Fetal-neonatal toxicity with prolonged use: Administration beyond 5 to 7 days is not recommended and can lead to hypocalcemia and bone abnormalities (2.2, 5.1)
  • Risk of magnesium toxicity: Monitor magnesium concentrations and clinical signs of magnesium toxicity including respiratory depression, an injectable calcium salt should be immediately available to counteract hazards, for significant toxicity stop Magnesium Sulfate in 5% Dextrose Injection (5.2)
  • Risk of elevated blood glucose: Solutions containing dextrose should be used with caution in patients with known prediabetes or diabetes mellitus (5.3)
  • Co-administration with unapproved tocolytics: Do not use concomitantly with beta adrenergic agents such as terbutaline and calcium channel blockers such as nifedipine (5.4)
  • Aluminum toxicity: Aluminum may reach toxic concentrations with prolonged parenteral administration in patients with renal impairment (5.5)
  • Exacerbation of Myasthenia Gravis: Use is contraindicated because use in patients with underlying myasthenia gravis can precipitate a myasthenic crisis (5.6)

ADVERSE REACTIONS

The most common adverse reactions are flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system (CNS) depression proceeding to respiratory paralysis and hypocalcemia. Bradycardia, pulmonary edema, decreased respiratory rate, lethargy, sedation, somnolence, visual disturbances, and hypermagnesemia are also reported (6)


To report SUSPECTED ADVERSE REACTIONS, contact Hospira, Inc. at 1-800-441-4100 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

DRUG INTERACTIONS

  • Neuromuscular blocking agents: Potentiation and prolongation of neuromuscular blockade is possible with the concomitant use of Magnesium Sulfate in 5% Dextrose Injection (7)
  • Narcotics and/or propofol: Potentiation and prolongation of analgesia and CNS depression is possible with the concomitant use of Magnesium Sulfate in 5% Dextrose Injection (7)
  • Dihydropyridine calcium channel blockers: An exaggerated hypotensive response is possible with the concomitant use of Magnesium Sulfate in 5% Dextrose Injection (7)
  • Drugs that may induce magnesium loss with concomitant use of Magnesium Sulfate in 5% Dextrose Injection: Alcohol, aminoglycosides, amphotericin B, cisplatin, cyclosporine, digitalis, loop diuretics, and thiazide diuretics (7)

USE IN SPECIFIC POPULATIONS

Patients with severe renal impairment and/or a urine output less than 100 mL every 4 hours are at greater risk for increased magnesium concentrations that may lead to toxicity (8.6)

See 17 for PATIENT COUNSELING INFORMATION.

Revised: 4/2019

Did you find an answer to your question? Yes No
Did you find an answer to your question? Yes No
Didn’t find what you were looking for? Contact us.
Report Adverse Event